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1.发明申请Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor 有权制备二肽基肽酶IV抑制剂及其中间体的方法公开(公告)号：US20100291642A1
公开(公告)日：2010-11-18
申请号：US12817370
申请日：2010-06-17
IPC分类号： C12P13/00
CPC分类号： C07D209/52 , C07H21/04 , C12N1/066 , C12N9/0008 , C12N9/0018 , C12P13/04 , C12P13/222 , C12P15/00 , C12P17/10 , C12Y102/02001
摘要： A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
摘要翻译： 提供了制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法，该方法采用BOC保护的胺，其结构是通过用甲酸铵，烟酰胺腺嘌呤二核苷酸处理酸来降低胺化而制备的结构 ，二硫苏糖醇和部分纯化的苯丙氨酸脱氢酶/甲酸脱氢酶浓缩物（PDH / FDH），并且不分离用二碳酸二叔丁酯处理所得结构2的胺以形成BOC保护的胺。
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2.发明申请Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor 失效制备二肽基肽酶IV抑制剂及其中间体的方法公开(公告)号：US20120276600A1
公开(公告)日：2012-11-01
申请号：US13523733
申请日：2012-06-14
IPC分类号： C07D209/52 , C12P13/00
CPC分类号： C07D209/52 , C07H21/04 , C12N1/066 , C12N9/0008 , C12N9/0018 , C12P13/04 , C12P13/222 , C12P15/00 , C12P17/10 , C12Y102/02001
摘要： A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine
摘要翻译： 提供了制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法，该方法采用BOC保护的胺，其结构是通过用甲酸铵，烟酰胺腺嘌呤二核苷酸处理酸来降低胺化而制备的结构 ，二硫苏糖醇和部分纯化的苯丙氨酸脱氢酶/甲酸脱氢酶浓缩物（PDH / FDH），并且不用二碳酸二叔丁酯处理得到的结构2的胺以形成BOC-保护的胺
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3.发明授权Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor 失效二肽基肽酶IV抑制剂及其中间体的制备方法公开(公告)号：US07741082B2
公开(公告)日：2010-06-22
申请号：US11104015
申请日：2005-04-12
CPC分类号： C07D209/52 , C07H21/04 , C12N1/066 , C12N9/0008 , C12N9/0018 , C12P13/04 , C12P13/222 , C12P15/00 , C12P17/10 , C12Y102/02001
摘要： A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
摘要翻译： 提供了制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法，该方法采用BOC保护的胺，其结构是通过用甲酸铵，烟酰胺腺嘌呤二核苷酸处理酸来降低胺化而制备的结构 ，二硫苏糖醇和部分纯化的苯丙氨酸脱氢酶/甲酸脱氢酶浓缩物（PDH / FDH），并且不分离用二碳酸二叔丁酯处理所得结构2的胺以形成BOC保护的胺。
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4.发明授权Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor 失效二肽基肽酶IV抑制剂及其中间体的制备方法公开(公告)号：US08361761B2
公开(公告)日：2013-01-29
申请号：US13523733
申请日：2012-06-14
CPC分类号： C07D209/52 , C07H21/04 , C12N1/066 , C12N9/0008 , C12N9/0018 , C12P13/04 , C12P13/222 , C12P15/00 , C12P17/10 , C12Y102/02001
摘要： A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
摘要翻译： 提供了制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法，该方法采用BOC保护的胺，其结构是通过用甲酸铵，烟酰胺腺嘌呤二核苷酸处理酸来降低胺化而制备的结构 ，二硫苏糖醇和部分纯化的苯丙氨酸脱氢酶/甲酸脱氢酶浓缩物（PDH / FDH），并且不分离用二碳酸二叔丁酯处理所得结构2的胺以形成BOC保护的胺。
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5.发明授权Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor 有权二肽基肽酶IV抑制剂及其中间体的制备方法公开(公告)号：US08222009B2
公开(公告)日：2012-07-17
申请号：US12817370
申请日：2010-06-17
CPC分类号： C07D209/52 , C07H21/04 , C12N1/066 , C12N9/0008 , C12N9/0018 , C12P13/04 , C12P13/222 , C12P15/00 , C12P17/10 , C12Y102/02001
摘要： A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
摘要翻译： 提供了制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法，该方法采用BOC保护的胺，其结构是通过用甲酸铵，烟酰胺腺嘌呤二核苷酸处理酸来降低胺化而制备的结构 ，二硫苏糖醇和部分纯化的苯丙氨酸脱氢酶/甲酸脱氢酶浓缩物（PDH / FDH），并且不分离用二碳酸二叔丁酯处理所得结构2的胺以形成BOC保护的胺。
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