专利检索 ap:("Michael Sotirios MALAMAS" OR "James Joseph ERDEI" OR "William Floyd FOBARE" OR "Dominick Anthony QUAGLIATO" OR "Schuyler Adam ANTANE" OR "Albert Jean ROBICHAUD") AND inv:"William Floyd FOBARE" 第 1 页

1.

发明申请
AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE 审中-公开
标题翻译：氨基-5- [4-（二氟甲基）苯基] -5-苯基咪唑烷酮化合物用于抑制β-分泌酶

公开(公告)号：US20090012139A1

公开(公告)日：2009-01-08

申请号：US12201026

申请日：2008-08-29

申请人： Michael Sotirios MALAMAS , James Joseph ERDEI , William Floyd FOBARE , Dominick Anthony QUAGLIATO , Schuyler Adam ANTANE , Albert Jean ROBICHAUD

发明人： Michael Sotirios MALAMAS , James Joseph ERDEI , William Floyd FOBARE , Dominick Anthony QUAGLIATO , Schuyler Adam ANTANE , Albert Jean ROBICHAUD

IPC分类号： C07D233/88 , A61K31/4168 , A61P25/00 , A61P25/28

CPC分类号： C07D233/88 , C07D401/12 , C07D409/12

摘要： The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

摘要翻译： 本发明提供式I的2-氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白的方法沉积物和神经原纤维缠结。