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1.发明申请公开(公告)号：US20080214845A1
公开(公告)日：2008-09-04
申请号：US12040615
申请日：2008-02-29
IPC分类号： C07D315/00
CPC分类号： C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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2.发明授权Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents 有权具有多个取代基的抗菌的4,5-取代的氨基糖苷类似物公开(公告)号：US08569264B2
公开(公告)日：2013-10-29
申请号：US13344247
申请日：2012-01-05
申请人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
发明人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： C07H15/23 , C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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3.发明授权Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents 有权具有多个取代基的抗菌的4,5-取代的氨基糖苷类似物公开(公告)号：US08114856B2
公开(公告)日：2012-02-14
申请号：US12987842
申请日：2011-01-10
申请人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
发明人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： C07H15/23 , C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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4.发明申请ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS 有权具有多种替代物的抗体4,5-取代的氨基酰胺类似物公开(公告)号：US20110166334A1
公开(公告)日：2011-07-07
申请号：US12987842
申请日：2011-01-10
申请人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
发明人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
IPC分类号： C07J41/00 , C07H15/232
CPC分类号： C07H15/23 , C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为预防或治疗微生物感染的制备和用途。
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5.发明申请ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS 有权具有多种替代物的抗体4,5-取代的氨基酰胺类似物公开(公告)号：US20080293649A1
公开(公告)日：2008-11-27
申请号：US12130048
申请日：2008-05-30
申请人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
发明人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
IPC分类号： A61K31/7036 , C07H15/232 , A61P31/04
CPC分类号： C07H15/23 , C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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6.发明授权Antibacterial 4,6-substituted 6′, 6″ and 1 modified aminoglycoside analogs 失效抗菌4,6-取代的6'，6“和1个修饰的氨基糖苷类似物公开(公告)号：US08377896B2
公开(公告)日：2013-02-19
申请号：US13044226
申请日：2011-03-09
CPC分类号： C07H15/234
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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7.发明申请ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS 有权具有多种替代物的抗体4,5-取代的氨基酰胺类似物公开(公告)号：US20130005674A1
公开(公告)日：2013-01-03
申请号：US13344247
申请日：2012-01-05
申请人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
发明人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
IPC分类号： A61K31/7036 , A61P31/04
CPC分类号： C07H15/23 , C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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8.发明申请ANTIBACTERIAL 4,6-SUBSTITUTED 6', 6" AND 1 MODIFIED AMINOGLYCOSIDE ANALOGS 失效抗菌素4,6-取代6'，6“和1修饰的氨基酰胺类似物公开(公告)号：US20110245476A1
公开(公告)日：2011-10-06
申请号：US13044226
申请日：2011-03-09
IPC分类号： C07H15/234
CPC分类号： C07H15/234
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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9.发明授权Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents 有权具有多个取代基的抗菌的4,5-取代的氨基糖苷类似物公开(公告)号：US07893039B2
公开(公告)日：2011-02-22
申请号：US12130048
申请日：2008-05-30
申请人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
发明人： Eric E. Swayze , Stephen Hanessian , Janek Szychowski , Susanta Sekhar Adhikari , Kandasamy Pachamuthu , Xiaojing Wang , Michael T. Migawa , Richard H. Griffey
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： C07H15/23 , C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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![Pyrazolo[3,4-c]pyridine compounds and methods of use](/abs-image/US/2016/02/16/US09260425B2/abs.jpg.150x150.jpg)
公开(公告)号：US09260425B2
公开(公告)日：2016-02-16
申请号：US13571595
申请日：2012-08-10
申请人： Steven Do , Huiyong Hu , Aleksandr Kolesnikov , Wendy Lee , Vickie H. Tsui , Xiaojing Wang , Zhaoyang Wen
发明人： Steven Do , Huiyong Hu , Aleksandr Kolesnikov , Wendy Lee , Vickie H. Tsui , Xiaojing Wang , Zhaoyang Wen
IPC分类号： C07D471/04 , C07D231/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/4995 , A61K31/506 , A61K31/55 , A61K31/551 , A61K45/06 , C07D231/00 , C07D519/00
摘要： Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式I的吡唑并[3,4-c]吡啶化合物，包括立体异构体，几何异构体，互变异构体及其药学上可接受的盐，其中R 1和R 2如本文所定义，可用于抑制Pim激酶， 由Pim激酶介导的癌症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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