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1.发明授权Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors 失效奎宁环衍生物的制备方法及其作为m2和/或m3毒蕈碱受体抑制剂的用途公开(公告)号：US07361668B2
公开(公告)日：2008-04-22
申请号：US10490436
申请日：2002-09-23
申请人： Michel Guyaux , Chimmanamada U. Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Matteo Zanda
发明人： Michel Guyaux , Chimmanamada U. Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Matteo Zanda
IPC分类号： A61K31/45 , A61K43/96 , A61K43/40 , C07D453/02
CPC分类号： C07D453/02
摘要： The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.
摘要翻译： 本发明涉及式I或II的奎宁环衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。 本发明化合物对于m 3和/或m 2毒蕈碱受体显示出高亲和力，特别适用于治疗尿失禁。
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2.发明申请Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors 失效奎宁环衍生物的制备方法及其作为m2和/或m3毒蕈碱受体抑制剂的用途公开(公告)号：US20050020660A1
公开(公告)日：2005-01-27
申请号：US10490436
申请日：2002-09-23
申请人： Michel Guyaux , Chimmanamada Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Mateo Zanda
发明人： Michel Guyaux , Chimmanamada Dinesh , Charles Mioskowski , Luc Quere , Jean-Philippe Starck , Patrice Talaga , Alain Wagner , Mateo Zanda
IPC分类号： A61K31/439 , A61K31/444 , A61P1/00 , A61P9/00 , A61P11/00 , A61P13/02 , A61P25/20 , A61P25/28 , C07D453/02 , C07F7/10 , C07D487/02 , A61K31/407
CPC分类号： C07D453/02
摘要： The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention_show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.
摘要翻译： 本发明涉及式I或II的奎宁环衍生物，其中取代基如说明书中所定义，以及它们作为药物的用途。 本发明的化合物对于m 3和/或m 2毒蕈碱受体具有高亲和力，并且特别适用于治疗尿失禁。
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3.发明申请公开(公告)号：US20070299118A1
公开(公告)日：2007-12-27
申请号：US11569605
申请日：2005-05-24
申请人： Jean-Philippe Starck , Benoit Kenda
发明人： Jean-Philippe Starck , Benoit Kenda
IPC分类号： A61K31/421 , A61P25/14 , A61P25/16 , C07D263/58
CPC分类号： C07D263/58
摘要： The present invention relates to benzoxazolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, in the treatment of movement disorders, in particular in Parkinson's disease.
摘要翻译： 本发明涉及苯并恶唑酮衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途，用于治疗运动障碍，特别是帕金森氏病。
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4.发明授权公开(公告)号：US08293775B2
公开(公告)日：2012-10-23
申请号：US11569605
申请日：2005-05-24
申请人： Jean-Philippe Starck , Benoît Kenda
发明人： Jean-Philippe Starck , Benoît Kenda
IPC分类号： C07D263/58 , A61K31/423
CPC分类号： C07D263/58
摘要： The present invention relates to benzoxazolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, in the treatment of movement disorders, in particular in Parkinson's disease.
摘要翻译： 本发明涉及苯并恶唑酮衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途，用于治疗运动障碍，特别是帕金森氏病。
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5.发明授权Indolone-acetamide derivatives, processes for preparing them and their uses 有权吲哚酮 - 乙酰胺衍生物，其制备方法及其用途公开(公告)号：US07964593B2
公开(公告)日：2011-06-21
申请号：US12622533
申请日：2009-11-20
申请人： Jean-Philippe Starck , Benoit Kenda
发明人： Jean-Philippe Starck , Benoit Kenda
IPC分类号： A61K31/4015 , C07D401/06 , C07D413/06 , C07D417/06
CPC分类号： C07D495/10 , C07D209/08 , C07D209/34
摘要： The present invention relates to indolone-acetamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as for the treatment of epilepsy, epileptogenesis, seizure disorders and convulsion.
摘要翻译： 本发明涉及吲哚酮乙酰胺衍生物，其制备方法，含有它们的药物组合物及其用于治疗癫痫，癫痫发作，癫痫发作和惊厥的用途。
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公开(公告)号：US20090012147A1
公开(公告)日：2009-01-08
申请号：US11572383
申请日：2005-07-14
申请人： Benoit Kenda , Jean-Philippe Starck
发明人： Benoit Kenda , Jean-Philippe Starck
IPC分类号： C07D209/34 , A61K31/405 , A61P25/08 , A61P25/28
CPC分类号： C07D209/34
摘要： The present invention relates to indolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
摘要翻译： 本发明涉及吲哚酮衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。
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7.发明申请Indolone-acetamide derivatives, processes for preparing them and their uses 有权吲哚酮 - 乙酰胺衍生物，其制备方法及其用途公开(公告)号：US20070043038A1
公开(公告)日：2007-02-22
申请号：US10550667
申请日：2004-03-16
申请人： Jean-Philippe Starck , Benoit Kenda
发明人： Jean-Philippe Starck , Benoit Kenda
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/404 , C07D413/02 , C07D417/02 , C07D403/02
CPC分类号： C07D495/10 , C07D209/08 , C07D209/34
摘要： The present invention relates to indolone-acetamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as for the treatment of epilepsy, epileptogenesis, seizure disorders and convulsion.
摘要翻译： 本发明涉及吲哚酮乙酰胺衍生物，其制备方法，含有它们的药物组合物及其用于治疗癫痫，癫痫发作，癫痫发作和惊厥的用途。
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8.发明申请METHOD FOR THE COMPARATIVE ANALYSIS OF PROTEIN PREPARATIONS BY MEANS OF NUCLEAR MAGNETIC RESONANCE 审中-公开通过核磁共振的蛋白质制备比较分析方法公开(公告)号：US20130069646A1
公开(公告)日：2013-03-21
申请号：US13520262
申请日：2010-12-30
IPC分类号： G01R33/465
CPC分类号： G01R33/465 , G01N24/08 , G01N24/087 , G01R33/4633
摘要： The invention relates to a method for the comparative analysis and control of the quality of a protein preparation by means of nuclear magnetic resonance (NMR) spectrometry. This method can be used to compare three-dimensional protein conformations in different protein preparations without requiring the samples to undergo any particular preparation. In particular, the method can be used to determine if a selected protein is in the same three-dimensional conformation in different protein preparations, if it is degraded in the formulation or if it is interacting with some of the excipients present. Specifically, the method can be used for the analysis and control of the quality of therapeutic compounds, particularly biodrugs or biosimilars, in different samples, without altering said samples.
摘要翻译： 本发明涉及通过核磁共振（NMR）光谱法比较分析和控制蛋白质制剂质量的方法。 该方法可用于比较不同蛋白质制剂中的三维蛋白质构象，而不需要样品进行任何特定的制备。 特别地，该方法可用于确定所选择的蛋白质在不同蛋白质制剂中是否处于相同的三维构象，如果其在制剂中降解，或者如果它与存在的一些赋形剂相互作用。 具体地，该方法可用于分析和控制不同样品中治疗化合物，特别是生物药物或生物仿制药的质量，而不改变所述样品。
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9.发明申请Indolone-Acetamide Derivatives, Processes for Preparing Them and Their Uses 有权吲哚酮 - 乙酰胺衍生物，其制备方法及其用途公开(公告)号：US20100069375A1
公开(公告)日：2010-03-18
申请号：US12622533
申请日：2009-11-20
申请人： Jean-Philippe Starck , Benoit Kenda
发明人： Jean-Philippe Starck , Benoit Kenda
IPC分类号： A61K31/541 , C07D209/34 , A61K31/404 , C07D401/02 , A61K31/4439 , C07D401/14 , A61K31/496 , C07D417/02 , C07D413/02 , A61K31/5377 , A61P25/00 , A61P11/00
CPC分类号： C07D495/10 , C07D209/08 , C07D209/34
摘要： The present invention relates to indolone-acetamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as for the treatment of epilepsy, epileptogenesis, seizure disorders and convulsion.
摘要翻译： 本发明涉及吲哚酮乙酰胺衍生物，其制备方法，含有它们的药物组合物及其用于治疗癫痫，癫痫发作，癫痫发作和惊厥的用途。
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10.发明授权Indolone-acetamide derivatives, processes for preparing them and their uses 有权吲哚酮 - 乙酰胺衍生物，其制备方法及其用途公开(公告)号：US07645887B2
公开(公告)日：2010-01-12
申请号：US10550667
申请日：2004-03-16
申请人： Jean-Philippe Starck , Benoît Kenda
发明人： Jean-Philippe Starck , Benoît Kenda
IPC分类号： C07D209/34 , A61K31/4015
CPC分类号： C07D495/10 , C07D209/08 , C07D209/34
摘要： The present invention relates to indolone-acetamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as for the treatment of epilepsy, epileptogenesis, seizure disorders and convulsion.
摘要翻译： 本发明涉及吲哚酮乙酰胺衍生物，其制备方法，含有它们的药物组合物及其用于治疗癫痫，癫痫发作，癫痫发作和惊厥的用途。
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