公开(公告)号：US08663155B2

公开(公告)日：2014-03-04

申请号：US11347779

申请日：2006-02-02

申请人： Michel J. N. Cormier ,  Wendy A. Young ,  Kofi Nyam ,  Peter E. Daddona ,  Wei-Qi Lin

发明人： Michel J. N. Cormier ,  Wendy A. Young ,  Kofi Nyam ,  Peter E. Daddona ,  Wei-Qi Lin

IPC分类号： A61M37/00

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

摘要翻译： 提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。 将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。 使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。 将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。

公开(公告)号：US07537795B2

公开(公告)日：2009-05-26

申请号：US10045842

申请日：2001-10-26

申请人： Michel J. N. Cormier ,  Wendy A. Young ,  Kofi Nyam ,  Peter E. Daddona

发明人： Michel J. N. Cormier ,  Wendy A. Young ,  Kofi Nyam ,  Peter E. Daddona

IPC分类号： B05D3/02

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

公开(公告)号：US20050106226A1

公开(公告)日：2005-05-19

申请号：US10970901

申请日：2004-10-21

申请人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

发明人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

IPC分类号： A61F13/00 ,  A61K9/00 ,  A61K9/70 ,  A61M20060101 ,  A61M37/00

CPC分类号： A61K9/7084 ,  A61K9/0021 ,  A61K9/703 ,  A61M37/0015 ,  A61M2037/0023

摘要： A drug delivery system for delivering a biologically active agent through the skin of a patient comprises (i) a pretreatment patch adapted to be placed on the patient's skin, the pretreatment patch having a backing membrane and a microprojection array, the microprojection array being adhered to the backing membrane, the microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, the pretreatment patch including a skin template that remains on the patient's skin after the pretreatment patch is applied to and removed from the patient's skin, and (ii) a gel patch having a top and bottom surface, the gel patch including a reservoir containing a hydrogel formulation, the gel patch having a skin contact area in the range of approximately 0.5-30 cm2.

摘要翻译： 用于递送生物活性剂通过患者皮肤的药物递送系统包括（i）适于放置在患者皮肤上的预处理贴剂，所述预处理贴片具有背衬膜和微突出物阵列，所述微突出物阵列粘附到 所述背衬膜，所述微突出物阵列包括适于刺穿所述患者角质层的多个微突出物，所述预处理贴片包括在将所述预处理贴片施加到患者皮肤并从患者皮肤移除之后残留在患者皮肤上的皮肤模板，以及 （ii）具有顶部和底部表面的凝胶贴片，所述凝胶贴片包括含有水凝胶制剂的储存器，所述凝胶贴片具有在约0.5-30cm 2范围内的皮肤接触面积。

公开(公告)号：US20050089554A1

公开(公告)日：2005-04-28

申请号：US10971430

申请日：2004-10-21

申请人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

发明人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

IPC分类号： A61K9/06 ,  A61K9/70 ,  A61K47/38 ,  A61L15/42 ,  A61L15/44 ,  A61L15/60 ,  A61M37/00 ,  A61F13/02 ,  A61L15/16 ,  A61M31/00

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/06 ,  A61K9/703 ,  A61K9/7084 ,  A61K47/38 ,  A61L15/425 ,  A61L15/44 ,  A61L15/60 ,  A61L2300/256 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053

摘要： An apparatus for transdermally delivering a biologically active agent comprising (i) a gel pack containing a hydrogel formulation and (ii) a microprojection member having top and bottom surfaces, a plurality of openings that extend through the microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of the microprojection member, the microprojection member being adapted to receive the gel pack whereby the hydrogel formulation flows through the microprojection member openings. Preferably, the hydrogel formulation comprises a water-based hydrogel.

摘要翻译： 一种用于透皮递送生物活性剂的装置，包括（i）含有水凝胶制剂的凝胶组件和（ii）具有顶表面和底表面的微突出物构件，延伸穿过微喷射构件的多个开口和多个角质层 - 从微突出物构件的所述底表面突出的刺穿微突起，所述微突出物构件适于接收凝胶包，由此水凝胶制剂流过微突出物构件开口。 优选地，水凝胶制剂包含水基水凝胶。

公开(公告)号：US20060200069A1

公开(公告)日：2006-09-07

申请号：US11347779

申请日：2006-02-02

申请人： Michel Cormier ,  Wendy Young ,  Kofi Nyam ,  Peter Daddona ,  Wei-Qi Lin

发明人： Michel Cormier ,  Wendy Young ,  Kofi Nyam ,  Peter Daddona ,  Wei-Qi Lin

IPC分类号： A61B17/20

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

摘要翻译： 提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。 将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。 使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。 将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。