公开(公告)号：US06258378B1

公开(公告)日：2001-07-10

申请号：US09243787

申请日：1999-02-03

申请人： Michel Schneider ,  Feng Yan ,  Agnés Hiver

发明人： Michel Schneider ,  Feng Yan ,  Agnés Hiver

IPC分类号： A61K9127

CPC分类号： A61K9/127 ,  A61K9/0009 ,  A61K41/0028 ,  Y10S424/812 ,  Y10S436/829

摘要： The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formulation comprising, dispersed in an aqueous carrier liquid, liposomes filled with bioactive substances and gas-filled microspheres, injecting said formulation into the circulation of a patient so that it is directed to a site of interest, and applying ultrasound pulses to said site so as to make the gas-filled microbodies explode and the gas confined therein to expand in the carrier liquid, the energy of expansion of said confined gas causing the liposome vesicles to open and release the trapped substances at said site. Also disclosed are formulations for delivery of biologically active substances to selected target sites in the organism, the formulations comprising an aqueous suspension of gas-filled microvesicles and liposomes filled with active susbstances such as drugs or diagnostic agents. The formulations are available in a kit form in which the kit comprises sterile precursor components.

摘要翻译： 本发明涉及一种用于向身体中选定部位的患者施用生物活性物质的方法，并远程促进将所述培养基递送至身体中选定的器官或组织。 该方法包括提供可施用的制剂，其包含在水性载体液体中分散有填充有生物活性物质和充气微球的脂质体，将所述制剂注射到患者的循环中，使其被引导到感兴趣的部位，并施加超声波 脉冲到所述位置，以使气体充填的微体体积膨胀，并且其中限制的气体在载体液体中膨胀，所述密闭气体的膨胀能使脂质体囊泡打开并释放所述位点处的被捕获的物质。 还公开了用于将生物活性物质递送到生物体中的选定靶位点的制剂，该制剂包含充满气体的微泡的水性悬浮液和填充有活性物质如药物或诊断剂的脂质体。 制剂可以试剂盒形式获得，其中试剂盒包含无菌前体组分。