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1.发明申请Compositions Comprising Solid Particles Entrapped in Collapsed Polymeric Microspheres, and Methods of Making the Same 有权包含在塌陷聚合物微球中的固体颗粒的组合物及其制备方法公开(公告)号：US20120045579A1
公开(公告)日：2012-02-23
申请号：US13227573
申请日：2011-09-08
IPC分类号： B05D7/00
CPC分类号： A61K8/025 , A61K8/0275 , A61K8/27 , A61K8/29 , A61K8/8164 , A61K9/0014 , A61K9/5026 , A61K9/5073 , A61K33/24 , A61K33/30 , A61K2800/412 , A61K2800/63 , A61Q17/04
摘要： The present invention relates to method for modifying or treating solid particles which includes the steps of: (a) forming a gelled mixture by mixing either simultaneously or sequentially in any order: (1) hollow microspheres each comprising a deformable polymeric shell having entrapped therein an expandable fluid, (2) a polar organic solvent capable of swelling but not dissolving the polymeric shells of the hollow microspheres, and (3) solid particles, wherein micro-channels are formed in the swelled polymer shells to allow entry of the solid particles into the hollow microspheres and exit of the expandable fluid therefrom, thereby forming microspheres that each comprises a collapsed polymeric shell in a gelled state and has one or more of said solid particles entrapped therein; (b) removing the expandable fluid and the polar organic solvent from the gelled mixture; and (c) coating the microspheres thus-produced with a film-forming material to form a liquid-impermeable membrane thereon.
摘要翻译： 本发明涉及固体颗粒改性或处理方法，其包括以下步骤：（a）通过以任何顺序同时或依次混合形成凝胶化混合物：（1）中空微球，其中包含可变形的聚合物壳， 可膨胀流体，（2）能够膨胀但不溶解中空微球的聚合物壳的极性有机溶剂，和（3）固体颗粒，其中在溶胀的聚合物壳中形成微通道以允许固体颗粒进入 中空微球体和可膨胀流体的出口，从而形成微球体，每个微球体包含胶凝状态的收缩的聚合物壳体，并且其中包含一个或多个所述固体颗粒; （b）从胶凝混合物中除去可膨胀流体和极性有机溶剂; 和（c）用成膜材料涂覆如此制备的微球，以在其上形成不透液膜。
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