公开(公告)号：US20180133221A1

公开(公告)日：2018-05-17

申请号：US15522715

申请日：2015-10-23

申请人： Millennium Pharmaceuticals, Inc.

发明人： Neil BENCE ,  Jessica HUCK ,  Marc HYER ,  Michael MILHOLLEN ,  Judy Qiuji SHI ,  Tary TRAORE

IPC分类号： A61K31/519 ,  A61K31/337 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K31/282 ,  A61K31/337 ,  A61K31/52 ,  A61K31/555 ,  A61K33/24 ,  A61K2300/00 ,  A61P35/00 ,  C07D231/38 ,  C07D405/12 ,  C07D487/04

摘要： Disclosed are methods for the treatment of cancer in patients in need of such treatment. The methods comprise administering to such a patient an ubiquitin-activating enzyme (UAE) inhibitor such as ((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-(3-(tri-fluoromethylthio)phenyl)pyrazolo [1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate (Compound 1) or a pharmaceutically acceptable salt in combination with one or more chemotherapeutic agents. Also disclosed are medicaments for use in the treatment of cancer.