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公开(公告)号:US20120037919A1
公开(公告)日:2012-02-16
申请号:US13266540
申请日:2010-09-14
申请人: Ming-sheng Xu , Hongzheng Chen , Minmin Shi , Gang Wu , Mang Wang
发明人: Ming-sheng Xu , Hongzheng Chen , Minmin Shi , Gang Wu , Mang Wang
CPC分类号: G01N33/48721 , B82Y15/00 , C12Q1/6869 , C12Q2565/631
摘要: A nanopore electrical sensor is provided. The sensor has layered structure, including a substrate (1), the first insulating layer (2), a symmetrical electrode (3) and the second insulating layer (5) from bottom to top in turn. A nanopore (6) is provided in the center of the substrate (1), the first insulating layer (2), the symmetrical electrode (3) and the second insulating layer (5). The thickness of the symmetrical electrode can be controlled between 0.3 nm and 0.7 nm so as to meet the resolution requirements for detecting a single base in a single-stranded DNA. Thus the sensor is suitable for gene sequencing. The present invention overcomes current technical insufficiency to integrate a nanoelectrode with a nanopore and the method to prepare the nanoelectrode is simple.
摘要翻译: 提供纳米孔电传感器。 该传感器依次具有层叠结构,包括基底(1),第一绝缘层(2),对称电极(3)和第二绝缘层(5)。 在基板(1),第一绝缘层(2),对称电极(3)和第二绝缘层(5)的中心设置有纳米孔(6)。 可以将对称电极的厚度控制在0.3nm和0.7nm之间,以满足检测单链DNA中单个碱基的分辨率要求。 因此,传感器适用于基因测序。 本发明克服了当前纳米电极纳米电极的技术不足,制备纳米电极的方法简单。