公开(公告)号：US5186943A

公开(公告)日：1993-02-16

申请号：US293108

申请日：1989-01-03

申请人： Minoru Okada ,  Toshiaki Horie ,  Hirohisa Okuyama ,  Syuichi Kasai ,  Akira Iwasa

发明人： Minoru Okada ,  Toshiaki Horie ,  Hirohisa Okuyama ,  Syuichi Kasai ,  Akira Iwasa

IPC分类号： A61K9/20 ,  A61K9/26

CPC分类号： A61K9/2081

摘要： Compressed-molded preparations are disclosed. In the preparation coated granules of a pharmaceutical composition are compressed and molded together with non-coated component(s) containing 10% or more by weight of non-swelling polymers. According to the preparation there is little breakdown of the coating of coated granules at the time of compressing and molding, and the rate of disintegration, and in turn, the release rate of the pharmaceutical component, can be freely controlled or modulated.

公开(公告)号：US5275825A

公开(公告)日：1994-01-04

申请号：US757983

申请日：1991-09-12

申请人： Minoru Okada ,  Toshiaki Horie ,  Hirohisa Okuyama ,  Syuichi Kasai ,  Akira Iwasa

发明人： Minoru Okada ,  Toshiaki Horie ,  Hirohisa Okuyama ,  Syuichi Kasai ,  Akira Iwasa

IPC分类号： A61K9/20 ,  A61K9/26 ,  A61K9/16

CPC分类号： A61K9/2081

摘要： Compressed molded preparations are disclosed. In the preparation coated granules of a pharmaceutical composition are compressed and molded together with non-coated component(s) containing 10% or more by weight of non-swelling polymers. According to the preparation there is little breakdown of the coating of coated granules at the time of compressing and molding, and the rate of disintegration, and in turn, the release rate of the pharmaceutical component, can be freely controlled or modulated.

摘要翻译： 公开了压缩成型制品。 在制备药物组合物的包衣颗粒中，与含有10重量％或更多重量的非溶胀聚合物的未涂覆组分一起压制和模塑。 根据制备，在压缩和模制时，涂层颗粒的涂层几乎没有破裂，并且可以自由地控制或调节崩解速率，进而释放出药物成分的释放速率。

公开(公告)号：US4968505A

公开(公告)日：1990-11-06

申请号：US353016

申请日：1989-05-17

申请人： Minoru Okada ,  Syuichi Kasai ,  Akira Iwasa

发明人： Minoru Okada ,  Syuichi Kasai ,  Akira Iwasa

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/52 ,  A61K9/56 ,  A61K31/19 ,  A61K31/195 ,  A61P29/00

CPC分类号： A61K9/5047 ,  A61K31/19 ,  A61K31/195 ,  A61K9/1617 ,  A61K9/5026 ,  A61K9/5073

摘要： A long-acting diclofenac sodium preparation is disclosed. The preparation comprises a sustained-release diclofenac sodium component which is prepared by coating a sustained-release coat onto a pharmaceutical composition comprising diclofenac sodium and an organic acid. It can decrease the maximum blood concentration of diclofenac by suppressing and controlling the rate of release of diclofenac sodium and maintain the blood concentration of diclofenac constant for a considerably long period of time. The risk of side-effect occurrences is reduced and patients is released from frequent administration of the medicine.

摘要翻译： 公开了一种长效双氯芬酸钠制剂。 该制剂包含持续释放的双氯芬酸钠组分，其通过将持续释放的涂层涂覆在包含双氯芬酸钠和有机酸的药物组合物上制备。 通过抑制和控制双氯芬酸钠的释放速度，可以降低双氯芬酸的最大血药浓度，并保持双氯芬酸的血药浓度持续相当长的一段时间。 副作用发生的风险降低，患者从药物的频繁使用中释放出来。

公开(公告)号：US06455053B1

公开(公告)日：2002-09-24

申请号：US09509988

申请日：2000-05-24

申请人： Minoru Okada ,  Yasuo Ikeda ,  Kenji Ono ,  Toshiaki Kurazumi ,  Syuichi Kasai ,  Katsumi Imamori

发明人： Minoru Okada ,  Yasuo Ikeda ,  Kenji Ono ,  Toshiaki Kurazumi ,  Syuichi Kasai ,  Katsumi Imamori

IPC分类号： A61K900

CPC分类号： A61K9/2095 ,  A61K9/0056

摘要： An orally administrable uncompressed rapidly dissolving molded dosage form comprises a drug and either one or more saccharides or one saccharide and polyvinylpyrrolidone. Saccarides are chosen and used in proportion based on their solubilities. Methods for producing uncompressed rapidly dissolving solid preparations comprise mixing a drug and carriers according to the present invention and charging the mixture in a mold. Rapidly dissolving oral dosage forms facilitate administration of drugs to patients having a difficulty in swallowing such as children and the elderly.

摘要翻译： 口服给药的未压缩的快速溶解的模塑剂型包含药物和一种或多种糖或一种糖和聚乙烯吡咯烷酮。 根据其溶解度选择和使用Saccarides成比例地使用。 用于生产未压缩的快速溶解固体制剂的方法包括混合根据本发明的药物和载体，并将混合物装入模具中。 快速溶解的口服剂型有助于向吞咽困难的患者（如儿童和老人）投放药物。

公开(公告)号：US20120189135A1

公开(公告)日：2012-07-26

申请号：US13437634

申请日：2012-04-02

申请人： Shinji Nabeshima ,  Syuichi Kasai

发明人： Shinji Nabeshima ,  Syuichi Kasai

IPC分类号： H03G3/00 ,  H04R1/10

CPC分类号： H04N7/17318 ,  H04N21/222 ,  H04N21/2743 ,  H04N21/2747 ,  H04N21/4852

摘要： A data transmitting/receiving method that reproduces content data distributed from a content server in a user terminal includes the user terminal connected to a network and a relay server in a system configuration. Request information that requests content data is transmitted from the user terminal to the relay server, the relay server reads volume adjustment information from a storing unit based on the request information to transmit the volume adjustment information to the user terminal, the user terminal adjusts a volume based on the volume adjustment information, the user terminal detects a volume change caused by a user operation to generate volume change information and transmits the volume change information from the user terminal to the relay server in association with content specifying information, and the relay server updates the volume adjustment information based on the volume change information.

摘要翻译： 再现从用户终端中的内容服务器分发的内容数据的数据发送/接收方法包括在系统配置中连接到网络的用户终端和中继服务器。 请求内容数据的请求信息从用户终端发送到中继服务器，中继服务器根据请求信息从存储单元读取音量调整信息，向用户终端发送音量调整信息，用户终端调整音量 基于音量调整信息，用户终端检测由用户操作引起的音量变化以产生音量变化信息，并且将音量变化信息从用户终端发送到与中继服务器相关的内容指定信息，并且中继服务器更新 基于音量变化信息的音量调节信息。