公开(公告)号：USRE34722E

公开(公告)日：1994-09-06

申请号：US937382

申请日：1992-08-31

申请人： Minoru Uchida ,  Makoto Komastu ,  Kazuyuki Nakagawa

发明人： Minoru Uchida ,  Makoto Komastu ,  Kazuyuki Nakagawa

IPC分类号： C07C205/57 ,  C07D209/38 ,  C07D215/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/06 ,  C07D417/12 ,  A61K31/47

CPC分类号： C07D215/227 ,  C07C205/57 ,  C07D209/38 ,  C07D215/18 ,  C07D215/26 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/06 ,  C07D417/12

摘要： Disclosed are carbostyril derivatives and their salts of the formulas ##STR1## The compounds have anti-peptic ulcer effects, and are useful as a treating agent for curing peptic ulcers in the digestive system, such as ulcers in the stomach and in the duodenum. The compounds particularly have prophylaxis and curing effects for treating chronic ulcers, for example experimental acetic acid-induced ulcers and cautery ulcers, with both low toxicity and few side-effects. Also disclosed are processes for preparing the compounds and for preparing pharmaceutical compositions containing them.

摘要翻译： 公开了喹诺酮衍生物及其下式的盐。该化合物具有抗消化性溃疡作用，并且可用作治疗消化系统中消化性溃疡的治疗剂，例如胃和十二指肠溃疡。 所述化合物特别具有用于治疗慢性溃疡的预防和治疗效果，例如实验性乙酸诱导的溃疡和烧灼性溃疡，具有低毒性和少量副作用。 还公开了制备化合物和制备含有它们的药物组合物的方法。

公开(公告)号：US4578381A

公开(公告)日：1986-03-25

申请号：US510241

申请日：1983-07-01

申请人： Minoru Uchida ,  Makoto Komastu ,  Kazuyuki Nakagawa

发明人： Minoru Uchida ,  Makoto Komastu ,  Kazuyuki Nakagawa

IPC分类号： C07C205/57 ,  C07D209/38 ,  C07D215/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/06 ,  C07D417/12 ,  A61K31/47

CPC分类号： C07D215/227 ,  C07C205/57 ,  C07D209/38 ,  C07D215/18 ,  C07D215/26 ,  C07D215/48 ,  C07D401/12 ,  C07D405/12 ,  C07D413/06 ,  C07D417/12

摘要： Disclosed are carbostyril derivatives and their salts of the formulas ##STR1## The compounds have anti-peptic ulcer effects, and are useful as a treating agent for curing peptic ulcers in the digestive system, such as ulcers in the stomach and in the duodenum. The compounds particularly have prophylaxis and curing effects for treating chronic ulcers, for example experimental acetic acid-induced ulcers and cautery ulcers, with both low toxicity and few side-effects. Also disclosed are processes for preparing the compounds and for preparing pharmaceutical compositions containing them.

摘要翻译： 公开了喹诺酮衍生物及其下式的盐。该化合物具有抗消化性溃疡作用，并且可用作治疗消化系统中消化性溃疡的治疗剂，例如胃和十二指肠溃疡。 所述化合物特别具有用于治疗慢性溃疡的预防和治疗效果，例如实验性乙酸诱导的溃疡和烧灼性溃疡，具有低毒性和少量副作用。 还公开了制备化合物和制备含有它们的药物组合物的方法。