公开(公告)号：US20190337922A1

公开(公告)日：2019-11-07

申请号：US16474461

申请日：2017-12-28

申请人： Minoryx Therapeutics S.L.

发明人： Ana Maria GARCÍA COLLAZO ,  Xavier BARRIL ALONSO ,  Elena CUBERO JORDÀ ,  Marc REVÉS VILAPLANA ,  Richard Spurring ROBERTS

IPC分类号： C07D401/06 ,  C07D239/49 ,  C07D401/12 ,  C07D405/12 ,  C07D403/06 ,  C07D251/18 ,  A61P43/00

摘要： The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.