公开(公告)号：US20220380487A1

公开(公告)日：2022-12-01

申请号：US17770986

申请日：2020-10-23

申请人： Minotaur Therapeutics, Inc.

发明人： Ruiqi Huang ,  Vaughn Smider

IPC分类号： C07K19/00 ,  C07K14/54 ,  C07K14/55 ,  C07K14/715

摘要： Provided are chimeric cytokine modified antibodies containing an ultralong CDR3, such as based on a bovine antibody sequence or a humanized sequence thereof, in which a portion of the CDR3 of the heavy chain is replaced by an interleukin (IL-15) or IL-2, and related antibodies. Among provided antibodies are chimeric IL-15 cytokine modified antibody molecules that are further linked or complexed with an extracellular portion of the IL15Rα, such as the IL15Rα sushi domain. Also provided are methods of making and using the chimeric cytokine modified antibodies.