公开(公告)号：US20230137025A1

公开(公告)日：2023-05-04

申请号：US17822667

申请日：2022-08-26

Applicant: Mirati Therapeutics, Inc.

Inventor： Matthew Arnold MARX ,  Matthew Randolph LEE ,  Thomas P. BOBINSKI ,  Aaron Craig BURNS ,  Nidhi ARORA ,  James Gail CHRISTENSEN ,  John Michael KETCHAM

IPC: C07D487/04

Abstract: The present invention relates to compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

公开(公告)号：US20210101904A1

公开(公告)日：2021-04-08

申请号：US17116270

申请日：2020-12-09

Applicant: Mirati Therapeutics, Inc.

Inventor： Matthew Arnold MARX ,  Matthew Randolph LEE ,  Thomas P. BOBINSKI ,  Aaron Craig BURNS ,  Nidhi ARORA ,  James Gail CHRISTENSEN ,  John Michael KETCHAM

IPC: C07D487/04

Abstract: The present invention relates to compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

公开(公告)号：US20210230168A1

公开(公告)日：2021-07-29

申请号：US17219379

申请日：2021-03-31

Applicant: Mirati Therapeutics, Inc.

Inventor： Matthew Arnold MARX ,  Matthew Randolph LEE ,  Thomas P. BOBINSKI ,  Aaron Craig BURNS ,  Nidhi ARORA ,  James Gail CHRISTENSEN ,  John Michael KETCHAM

IPC: C07D487/04

Abstract: The present invention relates to compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.