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公开(公告)号：US20230077225A1
公开(公告)日：2023-03-09
申请号：US17869575
申请日：2022-07-20
发明人： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC分类号： C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US10647715B2
公开(公告)日：2020-05-12
申请号：US16412091
申请日：2019-05-14
发明人： Matthew Arnold Marx , Thomas P. Bobinski , Aaron Craig Burns , John Gaudino , Julia Haas , John Michael Ketcham , John David Lawson , Brad Newhouse , Spencer Pajk , Christopher Ronald Smith , Tony P. Tang
IPC分类号： C07D471/04 , A61P35/00 , C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20200262837A1
公开(公告)日：2020-08-20
申请号：US16868258
申请日：2020-05-06
发明人： Matthew Arnold Marx , Thomas P. Bobinski , Aaron Craig Burns , John Gaudino , Julia Haas , John Michael Ketcham , John David Lawson , Brad Newhouse , Spencer Pajk , Christopher Ronald Smith , Tony P. Tang
IPC分类号： C07D471/04 , C07D491/08 , A61P35/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20190270743A1
公开(公告)日：2019-09-05
申请号：US16412091
申请日：2019-05-14
发明人： Matthew Arnold Marx , Thomas P. Bobinski , Aaron Craig Burns , John Gaudino , Julia Haas , John Michael Ketcham , John David Lawson , Brad Newhouse , Spencer Pajk , Christopher Ronald Smith , Tony P. Tang
IPC分类号： C07D471/04 , C07D519/00 , A61P35/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20230279025A1
公开(公告)日：2023-09-07
申请号：US18015691
申请日：2021-02-25
发明人： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James Francis Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC分类号： C07D519/00
CPC分类号： C07D519/00 , C07B2200/05
摘要： The present invention relates to compounds that inhibit KRas G12D, In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US11453683B1
公开(公告)日：2022-09-27
申请号：US17005004
申请日：2020-08-27
发明人： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P. A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC分类号： C07D519/00
摘要： Compounds that inhibit KRas G12D; in particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240309020A1
公开(公告)日：2024-09-19
申请号：US18644056
申请日：2024-04-23
发明人： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC分类号： C07D519/00
CPC分类号： C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US11964989B2
公开(公告)日：2024-04-23
申请号：US17869575
申请日：2022-07-20
发明人： Xiaolun Wang , Aaron Craig Burns , James Gail Christensen , John Michael Ketcham , John David Lawson , Matthew Arnold Marx , Christopher Ronald Smith , Shelley Allen , James F. Blake , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Macedonio J. Mejia , Brad Newhouse , Phong Nguyen , Jacob Matthew O'Leary , Spencer Pajk , Martha E. Rodriguez , Pavel Savechenkov , Tony P. Tang , Guy P.A. Vigers , Qian Zhao , Dean Russell Kahn , John Gaudino , Michael Christopher Hilton
IPC分类号： C07D519/00
CPC分类号： C07D519/00
摘要： Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I):
or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US20200308170A1
公开(公告)日：2020-10-01
申请号：US16869079
申请日：2020-05-07
发明人： Matthew Arnold Marx , Thomas P. Bobinski , Aaron Craig Burns , John Gaudino , Julia Haas , John Michael Ketcham , John David Lawson , Brad Newhouse , Spencer Pajk , Christopher Ronald Smith , Tony P. Tang
IPC分类号： C07D471/04 , A61P35/00 , C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US10154995B2
公开(公告)日：2018-12-18
申请号：US15684733
申请日：2017-08-23
发明人： James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC分类号： A61K31/506 , C07D417/14 , C07D405/14 , C07D403/04 , C07D401/14 , C07D471/04 , C07D403/14 , A61K31/4439 , A61K31/444 , A61K45/06
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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