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公开(公告)号:US20230357277A1
公开(公告)日:2023-11-09
申请号:US18027300
申请日:2021-09-21
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor: Xiaolun Wang , Matthew Arnold Marx , Shelley Allen , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Michael Christopher Hilton , Dean Russell Kahn , Macedonio Junior Mejia , Phong Nguyen , Spencer Pajk , Martha E. Rodriguez , Pavel Yu Savechenkov , Tony Pisal Tang
IPC: C07D519/00 , A61P35/00
CPC classification number: C07D519/00 , A61P35/00
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.