公开(公告)号：US20220105092A1

公开(公告)日：2022-04-07

申请号：US17554588

申请日：2021-12-17

申请人： Mirum Pharmaceuticals, Inc.

发明人： Thomas Jaecklin ,  Alejandro Dorenbaum

IPC分类号： A61K31/4995 ,  A61P1/16 ,  A61P17/04 ,  A61K31/554 ,  A61K31/7042

摘要： Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 μg/kg/day.

公开(公告)号：US20210113585A1

公开(公告)日：2021-04-22

申请号：US17119132

申请日：2020-12-11

申请人： Mirum Pharmaceuticals, Inc.

发明人： Thomas Jaecklin

IPC分类号： A61K31/554 ,  A61K31/4995 ,  A61K31/7042 ,  A61P1/16

摘要： Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 μg/kg/day.

公开(公告)号：US11918578B2

公开(公告)日：2024-03-05

申请号：US17960669

申请日：2022-10-05

申请人： Mirum Pharmaceuticals, Inc.

发明人： Thomas Jaecklin ,  Alejandro Dorenbaum

IPC分类号： A61K31/4995 ,  A61K31/554 ,  A61K31/7042 ,  A61P1/16 ,  A61P17/04 ,  G01N33/68

CPC分类号： A61K31/4995 ,  A61K31/554 ,  A61K31/7042 ,  A61P1/16 ,  A61P17/04 ,  G01N33/6893 ,  G01N2800/085

摘要： Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 μg/kg/day.

公开(公告)号：US11497745B2

公开(公告)日：2022-11-15

申请号：US17554588

申请日：2021-12-17

申请人： Mirum Pharmaceuticals, Inc.

发明人： Thomas Jaecklin ,  Alejandro Dorenbaum

IPC分类号： A61K31/4995 ,  A61P1/16 ,  A61P17/04 ,  A61K31/554 ,  A61K31/7042 ,  G01N33/68

摘要： Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 μg/kg/day.

公开(公告)号：US11229647B2

公开(公告)日：2022-01-25

申请号：US16994368

申请日：2020-08-14

申请人： Mirum Pharmaceuticals, Inc.

发明人： Thomas Jaecklin ,  Alejandro Dorenbaum

IPC分类号： A61K31/4995 ,  A61P1/16 ,  A61P17/04 ,  A61K31/554 ,  A61K31/7042

摘要： Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 μg/kg/day.