公开(公告)号：US20210253549A1

公开(公告)日：2021-08-19

申请号：US17162157

申请日：2021-01-29

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D401/04 ,  C07D233/64 ,  C07D405/10 ,  A61P21/00 ,  A61P25/00

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US10399958B2

公开(公告)日：2019-09-03

申请号：US15766455

申请日：2016-10-05

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D233/64 ,  C07D401/04 ,  C07D405/10 ,  A61P21/00 ,  A61P25/00

Abstract: Provided herein are compounds I, II or III and compositions useful in increasing PPAR8 activity. The compounds and compositions provided herein are useful for the treatment of PPAR8 related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US20190084958A1

公开(公告)日：2019-03-21

申请号：US15766455

申请日：2016-10-05

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D401/04 ,  A61P21/00 ,  A61P25/00 ,  C07D233/64

CPC classification number: C07D401/04 ,  A61P21/00 ,  A61P25/00 ,  C07D233/64 ,  C07D405/10

Abstract: Provided herein are compounds I, II or III and compositions useful in increasing PPAR8 activity. The compounds and compositions provided herein are useful for the treatment of PPAR8 related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US20240417383A1

公开(公告)日：2024-12-19

申请号：US18422793

申请日：2024-01-25

Applicant: Mitobridge, Inc. ,  The Salk Institute For Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D401/04 ,  A61P21/00 ,  A61P25/00 ,  C07D233/64 ,  C07D405/10

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US20190337920A1

公开(公告)日：2019-11-07

申请号：US16510976

申请日：2019-07-15

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D401/04 ,  A61P25/00 ,  C07D233/64 ,  C07D405/10 ,  A61P21/00

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US20230373948A1

公开(公告)日：2023-11-23

申请号：US18108785

申请日：2023-02-13

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D401/04 ,  C07D233/64 ,  C07D405/10 ,  A61P21/00 ,  A61P25/00

CPC classification number: C07D401/04 ,  C07D233/64 ,  C07D405/10 ,  A61P21/00 ,  A61P25/00

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US11578052B2

公开(公告)日：2023-02-14

申请号：US17162157

申请日：2021-01-29

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D233/64 ,  C07D401/04 ,  C07D405/10 ,  A61P21/00 ,  A61P25/00

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US10906885B2

公开(公告)日：2021-02-02

申请号：US16682676

申请日：2019-11-13

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D233/64 ,  C07D401/04 ,  C07D405/10 ,  A61P21/00 ,  A61P25/00

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US20200157074A1

公开(公告)日：2020-05-21

申请号：US16682676

申请日：2019-11-13

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D401/04 ,  C07D405/10 ,  A61P25/00 ,  A61P21/00 ,  C07D233/64

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

公开(公告)号：US10479775B1

公开(公告)日：2019-11-19

申请号：US16510976

申请日：2019-07-15

Applicant: Mitobridge, Inc. ,  The Salk Institute for Biological Studies

Inventor： Michael Downes ,  Ronald M. Evans ,  Arthur Kluge ,  Bharat Lagu ,  Masanori Miura ,  Sunil Kumar Panigrahi ,  Michael Patane ,  Susanta Samajdar ,  Ramesh Senaiar ,  Taisuke Takahashi

IPC: C07D401/04 ,  A61P25/00 ,  A61P21/00 ,  C07D405/10 ,  C07D233/64

Abstract: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).