公开(公告)号：US20230000773A1

公开(公告)日：2023-01-05

申请号：US17761863

申请日：2020-09-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY ,  Andrew MCKENZIE

IPC: A61K9/127 ,  C07D285/10 ,  C07D207/456 ,  C07D237/22 ,  C07D233/88 ,  C07D249/14 ,  C07D271/08 ,  C07D239/22 ,  C07D241/20 ,  C07C237/10 ,  C07D209/14 ,  C07D231/56 ,  C07C311/05 ,  C07F5/02 ,  C07F9/36 ,  C07D319/12 ,  C07D307/68 ,  C07D239/38 ,  C07D285/18 ,  A61K31/7105

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.