公开(公告)号：US20190167811A1

公开(公告)日：2019-06-06

申请号：US16092612

申请日：2017-04-13

Applicant: ModernaTX, Inc.

Inventor： Kerry BENENATO ,  Bo YING ,  Luis BRITO

IPC: A61K48/00 ,  A61P35/00 ,  A61K9/00 ,  A61K47/24 ,  A61K47/28 ,  A61K9/127 ,  A61K47/44

Abstract: The present application provides a composition comprising (1) a lipid composition comprising an ionizable amino lipid and a quaternary amine compound and (2) a polynucleotide. The present application also provides a composition comprising (1) a lipid composition comprising an asymmetric phospholipid, an ionizable amino lipid, and optionally a quaternary amine compound and (2) a polynucleotide, wherein the composition is formulated for intratumoral delivery of the polynucleotide. The present application further provides pharmaceutical compositions for intratumoral delivery comprising (1) a lipid composition comprising a compound of formula (I) and (2) therapeutic agent or a polynucleotide encoding the therapeutic agent, e.g., an mRNA encoding a therapeutic protein or a fragment thereof. Further provided is a method of increasing retention of a polynucleotide in a tumor tissue by using such a composition.