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公开(公告)号：US20230086537A1
公开(公告)日：2023-03-23
申请号：US17608359
申请日：2020-05-07
Applicant: ModernaTX, Inc.
Inventor： Ruchi JAIN , Gilles BESIN , Elizaveta ANDRIANOVA
IPC: C12N15/88 , A61K31/7088
Abstract: The disclosure features mRNAs engineered with one or more microRNA binding sites targeted by a microRNA(s) that are differentially expressed in a target immune cell relative to a plurality of non-target immune cells. The disclosure also features methods of using the same, for example, for selectively degrading the mRNA in the target immune cell relative to the plurality of non-target immune cells.
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