公开(公告)号：US11597698B2

公开(公告)日：2023-03-07

申请号：US17324426

申请日：2021-05-19

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise ,  Edward Hennessy ,  Ellalahewage S. Kumarasinghe

IPC: C07C229/12 ,  A61K47/00 ,  A61K9/00 ,  C07C229/24 ,  A61K47/54 ,  A61K9/127 ,  A61K31/713 ,  A61K48/00

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20230286903A1

公开(公告)日：2023-09-14

申请号：US18164136

申请日：2023-02-03

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark Cornebise ,  Edward Hennessy ,  Ellalahewage S. Kumarasinghe

IPC: C07C229/24 ,  A61K47/54 ,  A61K9/127 ,  A61K31/713 ,  A61K48/00

CPC classification number: C07C229/24 ,  A61K47/543 ,  A61K9/1272 ,  A61K31/713 ,  A61K48/0033 ,  A61K48/005

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US11066355B2

公开(公告)日：2021-07-20

申请号：US17025779

申请日：2020-09-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise ,  Edward Hennessy ,  Ellalahewage S. Kumarasinghe

IPC: C07C229/00 ,  A61K47/00 ,  A61K9/00 ,  C07C229/24 ,  A61K48/00 ,  A61K31/713 ,  A61K9/127 ,  A61K47/54

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.