公开(公告)号：US20230235298A1

公开(公告)日：2023-07-27

申请号：US17928680

申请日：2021-06-01

Applicant: ModernaTX, Inc.

Inventor： Lisa M. Rice ,  Patrick Finn ,  Athanasios Dousis

IPC: C12N9/02 ,  C12N15/63 ,  A61P3/00 ,  A61K9/127

CPC classification number: C12N9/0071 ,  C12Y114/16001 ,  C12N15/63 ,  A61P3/00 ,  A61K9/1271

Abstract: Variant phenylalanine hydroxylase polypeptides having substitutions at selected amino acid residues are disclosed. Also disclosed are methods of using variant phenylalanine hydroxylase polypeptides, or polynucleotides encoding variant phenylalanine hydroxylase polypeptides, to treat disorders such as phenylketonuria.