公开(公告)号：US12090235B2

公开(公告)日：2024-09-17

申请号：US17277994

申请日：2019-09-20

Applicant: ModernaTX, Inc.

Inventor： Allen Horhota ,  Christopher Karl McLaughlin ,  Jessica Cheney ,  Ben Geldhof ,  Jeffrey Hrkach ,  Melissa J. Moore ,  Stephen G. Hoge

IPC: A61K9/16 ,  A61K9/51 ,  A61K45/06

CPC classification number: A61K9/5192 ,  A61K9/5123 ,  A61K9/5146 ,  A61K45/06

Abstract: The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and the produced LNP formulations thereof. The present disclosure also provides therapeutic and diagnostic uses related to the produced LNP formulations.

公开(公告)号：US11485972B2

公开(公告)日：2022-11-01

申请号：US16614245

申请日：2018-05-18

Applicant: ModernaTX, Inc.

Inventor： Melissa J. Moore ,  Caroline Köhrer ,  Ruchi Jain ,  Vladimir Presnyak

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/11 ,  A61K47/69 ,  C12N15/85 ,  C12N15/88

Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide a desired translational regulatory activity to the mRNA.

公开(公告)号：US12241063B2

公开(公告)日：2025-03-04

申请号：US17933500

申请日：2022-09-20

Applicant: ModernaTX, Inc.

Inventor： Melissa J. Moore ,  Caroline Köhrer ,  Ruchi Jain ,  Vladimir Presnyak

IPC: C07H21/02 ,  A61K47/69 ,  C12N15/11 ,  C12N15/85 ,  C12N15/88

Abstract: The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide a desired translational regulatory activity to the mRNA.