公开(公告)号：US20220411361A1

公开(公告)日：2022-12-29

申请号：US17761984

申请日：2020-09-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Souvik BISWAS ,  Mark CORNEBISE ,  Edward HENNESSY ,  Ellalahewage S. KUMARASINGHE

IPC: C07C217/08 ,  A61K9/127

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.