公开(公告)号：US11873327B2

公开(公告)日：2024-01-16

申请号：US17875887

申请日：2022-07-28

Applicant: ModernaTX, Inc.

Inventor： Ankita Mishra ,  Joshua Frederick ,  Sushma Gurumurthy

IPC: C07K14/54 ,  A61K9/51 ,  A61K38/00

CPC classification number: C07K14/5434 ,  A61K9/5123 ,  A61K38/00 ,  C07K2319/03

Abstract: The present disclosure relates to polynucleotides encoding tethered interleukin-12 (IL-12) polypeptides comprising an IL-12 polypeptide and a membrane domain. The present disclosure also relates to vectors comprising the polynucleotides; host cells comprising the polynucleotides or vectors, polypeptides encoded by the polynucleotides; compositions comprising the polynucleotides, vectors, host cells, or polypeptides and a delivery agent; and uses thereof, including treatment of cancer.

公开(公告)号：US11421011B2

公开(公告)日：2022-08-23

申请号：US16613732

申请日：2018-05-18

Applicant: ModernaTX, Inc.

Inventor： Ankita Mishra ,  Joshua Frederick ,  Sushma Gurumurthy

IPC: C07K14/54 ,  A61K9/51 ,  A61K38/00

Abstract: The present disclosure relates to polynucleotides encoding tethered interleukin-12 (IL-12) polypeptides comprising an IL-12 polypeptide and a membrane domain. The present disclosure also relates to vectors comprising the polynucleotides; host cells comprising the polynucleotides or vectors, polypeptides encoded by the polynucleotides; compositions comprising the polynucleotides, vectors, host cells, or polypeptides and a delivery agent; and uses thereof, including treatment of cancer.