公开(公告)号：US10195156B2

公开(公告)日：2019-02-05

申请号：US16004850

申请日：2018-06-11

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  William Butcher

IPC: A61K9/51 ,  C07D295/185 ,  A61K38/18

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US12077501B2

公开(公告)日：2024-09-03

申请号：US16620666

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  William Butcher

IPC: A61K9/51 ,  A61K47/60 ,  C07D207/09 ,  C07D211/28 ,  A61K31/7105 ,  A61K45/06

CPC classification number: C07D211/28 ,  A61K9/51 ,  A61K47/60 ,  C07D207/09 ,  A61K31/7105 ,  A61K45/06

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US10799463B2

公开(公告)日：2020-10-13

申请号：US16065067

申请日：2016-12-22

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  William Butcher

IPC: A61K9/51 ,  C07D295/185 ,  C07D211/16 ,  C07D295/13 ,  C07D211/14 ,  A61K38/18 ,  A61K47/22 ,  A61K48/00 ,  C07D241/04 ,  A61K9/127 ,  B82Y5/00

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.