公开(公告)号：US08076341B2

公开(公告)日：2011-12-13

申请号：US12161081

申请日：2007-01-22

申请人： Mohammed Homman ,  Robert Engovist ,  Cecilia E Söderberg-Nauclér ,  Jan Bergman

发明人： Mohammed Homman ,  Robert Engovist ,  Cecilia E Söderberg-Nauclér ,  Jan Bergman

IPC分类号： A61K31/497 ,  A61K31/4965 ,  C07D471/00

CPC分类号： C07D487/04

摘要： A compound of formula (I) wherein R1 is selected from H, F, Cl, Br, CF3, C1-C6 alkoxy and OH; R2 is selected from H and C1-C6 alkyl; n is 1-12; m is O or 1; Y is selected from CH2, NR3, (NR3R4)+X, O and S; R3 and R4 are independently selected from H and C1-C4 alkyl; and X″ is selected from phannaceutically acceptable anions. A method of preparing the compound, its use as a pharmaceutical, and a method of treatment.

摘要翻译： 其中R 1选自H，F，Cl，Br，CF 3，C 1 -C 6烷氧基和OH的式（I）化合物; R2选自H和C1-C6烷基; n为1-12; m为O或1; Y选自CH 2，NR 3，（NR 3 R 4）+ X，O和S; R 3和R 4独立地选自H和C 1 -C 4烷基; 并且X“选自药学上可接受的阴离子。 制备化合物的方法，其作为药物的用途和治疗方法。