公开(公告)号：US20240285604A1

公开(公告)日：2024-08-29

申请号：US18633272

申请日：2024-04-11

Applicant: Monte Rosa Therapeutics, Inc.

Inventor： Laura Ann McAllister ,  Elisa Liardo ,  Andreas Ritzen ,  Vladas Oleinikovas ,  Xavier Lucas Cabré ,  Bernhard Fasching ,  Lorenzo Delarue Bizzini ,  Mathieu Lesieur

IPC: A61K31/4545 ,  A61P1/04 ,  A61P19/02 ,  A61P37/06 ,  C07D401/10

CPC classification number: A61K31/4545 ,  A61P1/04 ,  A61P19/02 ,  A61P37/06 ,  C07D401/10

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt thereof) that degrades Proto-oncogene VAV 1 protein (VAV1). The chemical entities are useful, e.g., for treating a subject (e.g., a human subject) having an inflammatory or autoimmune disorder.