公开(公告)号：US20230023026A1

公开(公告)日：2023-01-26

申请号：US17758422

申请日：2021-01-06

Applicant: Mor Research Applications Ltd.

Inventor： Orith Waisbourd-Zinman

IPC: A61K31/198 ,  A61K31/385 ,  A61K31/593 ,  A61K31/26 ,  A61K31/7076 ,  A61P1/16

Abstract: Methods of treating damaged bile ducts by way of elevating glutathione (GSH) levels, restoring normal GSH levels, and/or maintaining normal GSH levels in the biliary ducts are disclosed. A disclosed method comprises local treatment of damaged biliary ducts, e.g., by directly delivering to the bile ducts lumen of at least one active agent that promotes increasing of GSH production or inhibiting of GSH degradation in the biliary epithelial cells.