公开(公告)号：US06828392B2

公开(公告)日：2004-12-07

申请号：US09942079

申请日：2001-08-28

申请人： Morten Peter Meldal ,  Thomas Groth

发明人： Morten Peter Meldal ,  Thomas Groth

IPC分类号： C08G828

CPC分类号： C08G12/06 ,  C08G16/0231 ,  C08G73/024 ,  C08L61/20 ,  C08L61/30 ,  C08L61/32

摘要： A star-blocked polymeric material based on polyethylene glycol and having a uniform distribution of both hydroxy and amine functional groups throughout the polymeric material is described. The polymeric material, known as HYDRA (hydroxy and amine functionalized resin), is prepared by forming a polyimine compound by reacting an aldehyde and an amine. The polyimine is then reacted with a reducing agent to form a star-blocked polymeric material. HYDRA resins can be used, for example, as solid supports for organic synthesis, for enzymatic assays, for immobilization of biomolecules, for controlled release of drugs, and for chromatographic separations.

摘要翻译： 描述了基于聚乙二醇并且在整个聚合物材料中具有羟基和胺官能团均匀分布的星形封闭的聚合物材料。 称为HYDRA（羟基和胺官能化树脂）的聚合物材料通过使醛和胺反应形成聚亚胺化合物来制备。 然后将聚亚胺与还原剂反应以形成星形封闭的聚合物材料。 HYDRA树脂可以用作例如有机合成的固体载体，用于酶分析，用于固定生物分子，用于控释药物和用于色谱分离。

公开(公告)号：US06642334B2

公开(公告)日：2003-11-04

申请号：US09901343

申请日：2001-07-09

申请人： Morten Grøtli ,  Morten Peter Meldal

发明人： Morten Grøtli ,  Morten Peter Meldal

IPC分类号： C08F13008

CPC分类号： C08G65/3322 ,  C08L71/02 ,  C08L2205/05 ,  Y10S526/93 ,  Y10S526/936 ,  C08L2666/04

摘要： Described herein is a pentaalkyldisiloxane containing polymeric surfactant prepared by the copolymerization of an alkoxypolyoxyalkylenyl acrylate and an acrylate containing a pentaalkyldisiloxane group. A method for preparing beaded polyethylene glycol-based resins in silicone oil in the presence of a polymeric surfactant containing a pentaalkyldisiloxane group is also described. The average bead size can be controlled by varying the stirring rate, the polymerization temperature, the amount of surfactant, the type of solvent, and the amount of solvent. The surfactant does not interfere with the polymerization and can be removed together with residual silicone oil by a simple washing procedure. The resins can be used, for example, as a support for solid phase organic synthesis, as a chromatographic resin, as a resin for solid phase MAS-NMR spectroscopy, and as a carrier for drug molecules, various reagents, or scavengers.

摘要翻译： 本文描述了通过烷氧基聚氧化烯基丙烯酸酯和含有五烷基二硅氧烷基团的丙烯酸酯的共聚合制备的含五聚烷基二硅氧烷的聚合物表面活性剂。 还描述了在含有五烷基二硅氧烷基团的聚合物表面活性剂存在下在硅油中制备珠粒聚乙二醇基树脂的方法。 可以通过改变搅拌速度，聚合温度，表面活性剂的量，溶剂的种类和溶剂的量来控制平均粒径。 表面活性剂不会干扰聚合，并且可以通过简单的洗涤程序与残留的硅油一起除去。 树脂可以用作固相有机合成的载体，作为色谱树脂，用作固相MAS-NMR光谱的树脂，以及用作药物分子，各种试剂或清除剂的载体。