公开(公告)号：US06755824B2

公开(公告)日：2004-06-29

申请号：US10123830

申请日：2002-04-15

申请人： Mudit K. Jain ,  Milton M. Morris ,  Jeffrey A. Hall ,  Gregory P. Walcott ,  Bruce KenKnight ,  David S. Wood

发明人： Mudit K. Jain ,  Milton M. Morris ,  Jeffrey A. Hall ,  Gregory P. Walcott ,  Bruce KenKnight ,  David S. Wood

IPC分类号： A61B1818

CPC分类号： A61B18/1492 ,  A61B2218/002

摘要： An ablation catheter stores a platelet inhibitor substance within a plurality of pockets or recesses of its shaft. The substance is adapted to elute upon contact with biological fluid. In the pocket configuration, the platelet inhibitor substance is in a capsule positioned within the pocket. In the recess configuration, the platelet inhibitor substance is in a hydrogel or silicone-based porous/semi-porous matrix positioned within the recess. Elution of the platelet inhibitor substance prevents or at least substantially minimizes the adhesion of blood platelets on the catheter surface during ablation. In another configuration, the catheter includes an internal lumen network having apertures terminating at the surface of the shaft. The lumen communicates with a source of platelet inhibitor fluid that is forced through the lumen by a variable pump.

摘要翻译： 消融导管将血小板抑制剂物质存储在其轴的多个口袋或凹槽内。 该物质适于在与生物液体接触时洗脱。 在口袋结构中，血小板抑制物质位于口袋内的胶囊中。 在凹陷结构中，血小板抑制剂物质是位于凹陷内的水凝胶或硅酮基多孔/半多孔基体。 血小板抑制剂物质的洗脱防止或至少基本上最小化在消融期间血小板在导管表面上的粘附。 在另一种构造中，导管包括内孔管网，其具有终止于轴表面处的孔。 管腔与血小板抑制剂流体源连通，该血小板抑制剂流体通过可变泵被迫通过内腔。

公开(公告)号：US06666862B2

公开(公告)日：2003-12-23

申请号：US09797435

申请日：2001-03-01

申请人： Mudit K. Jain ,  Milton M. Morris ,  Bruce KenKnight

发明人： Mudit K. Jain ,  Milton M. Morris ,  Bruce KenKnight

IPC分类号： A61B1818

CPC分类号： A61B18/1492 ,  A61B18/16 ,  A61B2018/0016 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00714 ,  A61B2018/00726 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/1273 ,  A61B2018/1286 ,  A61B2018/1467 ,  A61B2090/065

摘要： Information indicative of the flow rate of fluid through a biological organ is provided to a processor. Using this information the processor assesses whether the fluid-flow rate is high or low and controls a generator such that the generator provides energy to an electrode positioned within the organ to effect tissue ablation. Energy of a first level is provided during periods of high fluid-flow and energy of a second level, less than the first level, during periods of low fluid-flow. The flow rate information may be provided by an electrocardiograph (ECG) device or a flow sensor. A temperature sensor provides temperature signals to the processor indicative of the electrode temperature. The processor further controls the generator based on the electrode temperature to maintain the temperature at or near a target temperature and below a maximum threshold temperature.

公开(公告)号：US06740080B2

公开(公告)日：2004-05-25

申请号：US09945097

申请日：2001-08-31

申请人： Mudit K. Jain ,  Milton M. Morris ,  Bruce KenKnight

发明人： Mudit K. Jain ,  Milton M. Morris ,  Bruce KenKnight

IPC分类号： A61B1812

CPC分类号： A61B18/1206 ,  A61B18/16 ,  A61B2018/00755 ,  A61B2018/00875 ,  A61B2018/1467

摘要： An apparatus for delivering energy to a biological site includes a catheter having an ablation electrode and a plurality of backplates distributed at various locations proximal the biological site. The backplates are coupled to a switching device for selecting which backplate to utilize as a return electrode to complete the circuit with the ablation electrode in order to obtain deeper, larger lesions for a given amount of energy. The backplate selection is made by determining which return electrode most closely places the biological site between the ablation electrode and the backplate. Backplate selection may be made automatically based on impedance measurements or conduction time measurements. Alternatively, the backplate selection can be made manually.

摘要翻译： 用于向生物部位输送能量的装置包括具有消融电极的导管和分布在生物部位附近的各个位置处的多个背板。 背板耦合到开关装置，用于选择哪个背板用作返回电极以用消融电极完成电路，以便为给定量的能量获得更深更大的损伤。 通过确定哪个返回电极最接近放置消融电极和背板之间的生物位点来进行背板选择。 可以基于阻抗测量或导通时间测量自动进行背板选择。 或者，可以手动进行背板选择。

公开(公告)号：US06955675B2

公开(公告)日：2005-10-18

申请号：US10037663

申请日：2002-01-03

申请人： Mudit K. Jain

发明人： Mudit K. Jain

IPC分类号： A61B18/14 ,  A61B18/18

CPC分类号： A61B18/1492 ,  A61B18/16 ,  A61B2018/0016 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00714 ,  A61B2018/00726 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00839 ,  A61B2018/00863 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/1273 ,  A61B2018/1286 ,  A61B2018/1467 ,  A61B2090/065

摘要： A distal segment of a catheter shaft is adapted to be positioned against tissue in a biological organ. The distal segment has a tissue-contacting area intended to contact the tissue. One or more pressure sensors positioned within the tissue-contacting area provide pressure data indicative of the pressure exerted on the distal segment. The distal segment carries one or more electrodes and the pressure sensors are located either on an electrode or on the catheter shaft near an electrode. The pressure sensors provide pressure data to a processor that analyzes the data to determine if the tissue-contacting area of the distal segment is contacting the tissue. The pressure sensors may also provide temperature data indicative of the temperature at the sensor. A flow sensor, located opposite the pressure sensor on the shaft, provides data related to the flow rate of fluid through the organ.

摘要翻译： 导管轴的远侧部分适于被定位成抵抗生物器官中的组织。 远端段具有用于接触组织的组织接触区域。 位于组织接触区域内的一个或多个压力传感器提供指示施加在远侧段上的压力的压力数据。 远端段携带一个或多个电极，并且压力传感器位于电极附近或电极附近的导管轴上。 压力传感器向分析数据的处理器提供压力数据，以确定远端段的组织接触区域是否与组织接触。 压力传感器还可提供指示传感器温度的温度数据。 与轴上的压力传感器相对的流量传感器提供与通过器官的流体流速相关的数据。