公开(公告)号：US20170166524A1

公开(公告)日：2017-06-15

申请号：US15435084

申请日：2017-02-16

申请人： Muneaki KURIMURA ,  Shinichi TAIRA ,  Takahiro TOMOYASU ,  Nobuaki ITO ,  Kuninori TAI ,  Noriaki TAKEMURA ,  Takayuki MATSUZAKI ,  Yasuhiro MENJO ,  Shin MIYAMURA ,  Yohji SAKURAI ,  Akihito WATANABE ,  Yasuyo SAKATA ,  Takumi MASUMOTO ,  Kohei AKAZAWA ,  Haruhiko SUGINO ,  Naoki AMADA ,  Satoshi OHASHI ,  Tomoichi SHINOHARA ,  Hirofumi SASAKI ,  Chisako MORITA ,  Junko YAMASHITA ,  Satoko NAKAJIMA

发明人： Muneaki KURIMURA ,  Shinichi TAIRA ,  Takahiro TOMOYASU ,  Nobuaki ITO ,  Kuninori TAI ,  Noriaki TAKEMURA ,  Takayuki MATSUZAKI ,  Yasuhiro MENJO ,  Shin MIYAMURA ,  Yohji SAKURAI ,  Akihito WATANABE ,  Yasuyo SAKATA ,  Takumi MASUMOTO ,  Kohei AKAZAWA ,  Haruhiko SUGINO ,  Naoki AMADA ,  Satoshi OHASHI ,  Tomoichi SHINOHARA ,  Hirofumi SASAKI ,  Chisako MORITA ,  Junko YAMASHITA ,  Satoko NAKAJIMA

IPC分类号： C07D205/04 ,  C07D413/12 ,  C07D409/12 ,  C07D405/12 ,  C07D471/04 ,  C07D417/12 ,  C07D495/04 ,  C07D409/14 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D205/04 ,  C07D207/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07F7/10

摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

公开(公告)号：US20140288065A1

公开(公告)日：2014-09-25

申请号：US14300619

申请日：2014-06-10

申请人： Muneaki KURIMURA ,  Shinichi TAIRA ,  Takahiro TOMOYASU ,  Nobuaki ITO ,  Kuninori TAI ,  Noriaki TAKEMURA ,  Takayuki MATSUZAKI ,  Yasuhiro MENJO ,  Shin MIYAMURA ,  Yohji SAKURAI ,  Akihito WATANABE ,  Yasuyo SAKATA ,  Takumi MASUMOTO ,  Kohei AKAZAWA ,  Haruhiko SUGINO ,  Naoki AMADA ,  Satoshi OHASHI ,  Tomoichi SHINOHARA ,  Hirofumi SASAKI ,  Chisako MORITA ,  Junko YAMASHITA ,  Satoko NAKAJIMA

发明人： Muneaki KURIMURA ,  Shinichi TAIRA ,  Takahiro TOMOYASU ,  Nobuaki ITO ,  Kuninori TAI ,  Noriaki TAKEMURA ,  Takayuki MATSUZAKI ,  Yasuhiro MENJO ,  Shin MIYAMURA ,  Yohji SAKURAI ,  Akihito WATANABE ,  Yasuyo SAKATA ,  Takumi MASUMOTO ,  Kohei AKAZAWA ,  Haruhiko SUGINO ,  Naoki AMADA ,  Satoshi OHASHI ,  Tomoichi SHINOHARA ,  Hirofumi SASAKI ,  Chisako MORITA ,  Junko YAMASHITA ,  Satoko NAKAJIMA

IPC分类号： C07D207/14 ,  C07D403/12 ,  C07D413/14 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12

CPC分类号： C07D205/04 ,  C07D207/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07F7/10

摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

摘要翻译： 本发明提供通式（1）的吡咯烷化合物或其盐，其中R 101和R 102各自独立地为苯基或吡啶基，苯基或吡啶基可以具有一个或多个选自卤素原子的取代基 和任选被一个或多个卤素原子取代的低级烷基等。本发明的吡咯烷化合物或其盐可用于制备具有较宽治疗谱的药物制剂，并能在短期内表现出足够的治疗效果 行政。

公开(公告)号：US20120065162A1

公开(公告)日：2012-03-15

申请号：US13298336

申请日：2011-11-17

申请人： Muneaki KURIMURA ,  Shinichi TAIRA ,  Takahiro TOMOYASU ,  Nobuaki ITO ,  Kuninori TAI ,  Noriaki TAKEMURA ,  Takayuki MATSUZAKI ,  Yasuhiro MENJO ,  Shin MIYAMURA ,  Yohji SAKURAI ,  Akihito WATANABE ,  Yasuyo SAKATA ,  Takumi MASUMOTO ,  Kohei AKAZAWA ,  Haruhiko SUGINO ,  Naoki AMADA ,  Satoshi OHASHI ,  Tomoichi SHINOHARA ,  Hirofumi SASAKI ,  Chisako MORITA ,  Junko YAMASHITA ,  Satoko NAKAJIMA

发明人： Muneaki KURIMURA ,  Shinichi TAIRA ,  Takahiro TOMOYASU ,  Nobuaki ITO ,  Kuninori TAI ,  Noriaki TAKEMURA ,  Takayuki MATSUZAKI ,  Yasuhiro MENJO ,  Shin MIYAMURA ,  Yohji SAKURAI ,  Akihito WATANABE ,  Yasuyo SAKATA ,  Takumi MASUMOTO ,  Kohei AKAZAWA ,  Haruhiko SUGINO ,  Naoki AMADA ,  Satoshi OHASHI ,  Tomoichi SHINOHARA ,  Hirofumi SASAKI ,  Chisako MORITA ,  Junko YAMASHITA ,  Satoko NAKAJIMA

IPC分类号： A61K31/695 ,  A61K31/40 ,  C07D403/12 ,  C07D239/24 ,  C07D401/12 ,  A61K31/501 ,  A61K31/506 ,  C07D491/04 ,  A61K31/519 ,  C07D265/36 ,  A61K31/538 ,  C07D241/10 ,  A61K31/497 ,  C07F7/10 ,  A61P9/12 ,  A61P25/18 ,  A61P25/24 ,  A61P25/30 ,  A61P25/22 ,  A61P25/28 ,  A61P25/00 ,  A61P25/16 ,  C07D207/12

CPC分类号： C07D205/04 ,  C07D207/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07F7/10

摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

摘要翻译： 本发明提供通式（1）的吡咯烷化合物或其盐，其中R 101和R 102各自独立地为苯基或吡啶基，苯基或吡啶基可以具有一个或多个选自卤素原子的取代基 和任选被一个或多个卤素原子取代的低级烷基等。本发明的吡咯烷化合物或其盐可用于制备具有较宽治疗谱的药物制剂，并能在短期内表现出足够的治疗效果 行政。