公开(公告)号：US4784856A

公开(公告)日：1988-11-15

申请号：US83886

申请日：1987-08-10

申请人： Mutsumi Fukuda ,  Takashi Nakagawa ,  Takaji Kishi ,  Michiharu Ando ,  Masahachi Yoshioka

发明人： Mutsumi Fukuda ,  Takashi Nakagawa ,  Takaji Kishi ,  Michiharu Ando ,  Masahachi Yoshioka

IPC分类号： A61K9/70 ,  A61L15/58 ,  A61F13/02 ,  A61F13/00 ,  A61K31/79 ,  A61L15/06

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61L15/58

摘要： A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material and an active ingredient compatible with said adhesive base material, wherein said adhesive base material is a copolymer containing 2-ethylhexyl acrylate (EHA) in a concentration of 45 mole% or more and N-vinyl-2-pyrrolidone (VP) in a concentration of 20 to 55 mole%, and said active ingredient is isosorbide dinitrate (ISDN) which is contained in a concentration of 10% by weight or more in said adhesive base material.

摘要翻译： 一种胶带形式的经皮给药型药物制剂，其包含不能被活性成分渗透的柔性背衬和形成在所述柔性背衬上的粘合剂基层; 所述粘合剂基层基本上由粘合剂基材和与所述粘合剂基材相容的活性成分组成，其中所述粘合剂基材是含有浓度为45摩尔％以上的丙烯酸2-乙基己酯（EHA）和N- 浓度为20〜55摩尔％的乙烯基-2-吡咯烷酮（VP），所述活性成分为所述粘合剂基材中浓度为10重量％以上的硝酸异山梨酯（ISDN）。