公开(公告)号：US20230151065A1

公开(公告)日：2023-05-18

申请号：US17303273

申请日：2019-04-10

申请人： NANTONG UNIVERSITY ,  DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES

发明人： Xiaozhe ZHANG ,  Fei DING ,  Qiong CHENG ,  Xiaosong GU ,  Xinmiao LIANG ,  Yunpeng BAI ,  Dengbing YAO ,  Ying YUAN ,  Caiping WANG ,  Jian YANG ,  Shu YU

IPC分类号： C07K14/415 ,  A61K38/00

CPC分类号： C07K14/415 ,  A61K38/00

摘要： A multi-disulfide-bond long-chain peptide with neuroprotective activity can reduce cellular calcium influx by inhibiting glutamate receptors to protect cortical neurons from excitotoxicity induced by glutamate. It can be an effective neuroprotective agent.

公开(公告)号：US20210155591A1

公开(公告)日：2021-05-27

申请号：US17047357

申请日：2019-04-11

申请人： DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES

发明人： Xinmiao LIANG ,  Yaopeng ZHAO ,  Yanfang LIU ,  Jixia WANG ,  Changjian WANG ,  Zhiwei WANG ,  Nana DU ,  Xiuli ZHANG ,  Zhimou GUO ,  Chaoran WANG

IPC分类号： C07D211/22 ,  C07D211/14 ,  C07D207/08 ,  C07D409/06 ,  A61P11/06

摘要： The disclosure relates to a 2-(2,2-diarylethyl)-cyclic amine derivative or salt, a synthesis method, an application and a composition thereof. Biological activity test shows that this kind of 2-(2,2-diarylethyl)-cyclic amine derivative has good M-receptor antagonistic activity; and can be used as an active component of drugs for the treatment of the diseases mediated or regulated by muscarinic receptors, such as asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchospasm with chronic obstructive pulmonary disease, visceral spasm, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia and related mental diseases.