公开(公告)号：US20230348436A1

公开(公告)日：2023-11-02

申请号：US17780235

申请日：2020-11-26

申请人： NANYANG TECHNOLOGICAL UNIVERSITY ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

发明人： Gerhard GRUBER ,  Roderick Wayland BATES ,  Shuyi Pearly NG

IPC分类号： C07D403/12 ,  A61K31/4709 ,  A61K31/506 ,  A61P31/06

CPC分类号： C07D403/12 ,  A61K31/4709 ,  A61K31/506 ,  A61P31/06

摘要： The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.