公开(公告)号：US20230288338A1

公开(公告)日：2023-09-14

申请号：US17911452

申请日：2021-03-17

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Ryo NISHIHARA ,  Ryoji KURITA

IPC: G01N21/64 ,  C07D487/04 ,  G01N33/68

CPC classification number: G01N21/6428 ,  C07D487/04 ,  G01N33/6803 ,  G01N2021/6439

Abstract: The present invention provides a novel compound or the like useful as a luminescent molecule serving as a substrate for a human-derived protein. The compound according to the present invention is a compound represented by the following formula [I], or a salt thereof, or a hydrate or solvate thereof.

公开(公告)号：US20180273539A1

公开(公告)日：2018-09-27

申请号：US15926204

申请日：2018-03-20

Applicant: KEIO UNIVERSITY ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  The University of Tokyo

Inventor： Koji SUZUKI ,  Daniel CITTERIO ,  Ryo NISHIHARA ,  Sung-Bae KIM ,  Moritoshi SATO ,  Takahiro NAKAJIMA

IPC: C07D487/04 ,  C07D405/06 ,  C09K11/06 ,  C12Q1/66

CPC classification number: C07D487/04 ,  C07D405/06 ,  C09K11/06 ,  C09K2211/1022 ,  C12Q1/66

Abstract: There is provided a series of coelenterazine (CTZ) derivatives as a substrate with high luminescence intensity, which is optimal for maximum luminescence wavelengths at both 400 nm (blue-shifted RLuc luminescence system) and 500 nm (ALuc luminescence system) for bioassays which is more sensitive than known techniques. The novel CTZ derivatives are compounds in which a specific position(s) of the CTZ is/are substituted with a specific substituent(s) as shown, for example, by the Formula [I], and has a higher luminescence intensity than known CTZ derivatives in blue-shifted RLuc luminescence system or ALuc luminescence system.