公开(公告)号：US20230338532A1

公开(公告)日：2023-10-26

申请号：US18044429

申请日：2021-09-10

Applicant: NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Antonio BERTOLETTI ,  Anthony Tanoto TAN ,  Morteza HAFEZI

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C12N9/16 ,  C12N9/04

CPC classification number: A61K39/4632 ,  A61K39/4611 ,  A61K39/4622 ,  A61K39/464463 ,  A61K39/464454 ,  A61K39/464838 ,  A61P35/00 ,  C07K14/7051 ,  C12N9/16 ,  C12Y301/03016 ,  C12N9/0006 ,  C12Y101/01205 ,  A61K2239/53

Abstract: Described are novel immunosuppressant drug resistant armored (IDRA) T cells that co-express an exogenous T cell receptor (TCR) and one or more exogenous inhibitors of an immunosuppressant. The TCR can bind to an antigen expressed by a tumor cell or virally infected cell. Also described are methods of producing the modified T cell, and methods of treating a subject using the modified T cells.