公开(公告)号：US20230130144A1

公开(公告)日：2023-04-27

申请号：US17915275

申请日：2021-03-30

申请人： NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD.

发明人： Nuo XU ,  Jian LIN

IPC分类号： A61K31/375 ,  A61K45/06 ,  A61P35/00

摘要： The present application relates to a pharmaceutical combination, comprising: a) a prophylactically and/or therapeutically effective amount of ascorbic acid or a derivative thereof; and b) a prophylactically and/or therapeutically effective amount of a second therapeutic agent selected from the group consisting of: a Notch signaling pathway inhibitor, an HH signaling pathway inhibitor, a Porcupine inhibitor, an RXRα inhibitor, Niclosamide, a CK1a inhibitor, and a Frizzled receptor inhibitor.

公开(公告)号：US20230338345A1

公开(公告)日：2023-10-26

申请号：US17918604

申请日：2021-04-22

申请人： NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD.

发明人： Nuo XU ,  Jian LIN

IPC分类号： A61K31/44 ,  A61K31/375 ,  A61K31/555 ,  A61K33/243 ,  A61P35/00

CPC分类号： A61K31/44 ,  A61K31/375 ,  A61K31/555 ,  A61K33/243 ,  A61P35/00

摘要： Provided is a drug combination for prevention and/or treatment of tumors. The drug combination includes: a) an ascorbic acid or a derivative thereof in an amount effective for prevention and/or treatment, and b) a selective PDE4 inhibitor in an amount effective for prevention and/or treatment.

公开(公告)号：US20240316015A1

公开(公告)日：2024-09-26

申请号：US18262475

申请日：2022-01-20

申请人： NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD.

发明人： Nuo XU ,  Jian LIN

IPC分类号： A61K31/44 ,  A61K31/4015 ,  A61K31/47 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04

CPC分类号： A61K31/44 ,  A61K31/4015 ,  A61K31/47 ,  A61K39/3955 ,  A61P35/00 ,  A61P35/04

摘要： A composition and a method for treating tumors. The method includes administering an effective amount of one or more immune checkpoint inhibitors, and an effective amount of a PDE4-selective inhibitor. The composition and the method have a significant anti-tumor effect.

公开(公告)号：US20230181524A1

公开(公告)日：2023-06-15

申请号：US17915326

申请日：2021-03-30

申请人： NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD.

发明人： Nuo XU ,  Jian LIN

IPC分类号： A61K31/375 ,  A61K31/713 ,  A61P35/00 ,  A61K31/517 ,  A61K31/519 ,  A61P19/00

CPC分类号： A61K31/375 ,  A61K31/713 ,  A61P35/00 ,  A61K31/517 ,  A61K31/519 ,  A61P19/00

摘要： A pharmaceutical combination for preventing and/or treating cancer and a kit. The pharmaceutical combination comprises: a) a prophylactically and/or therapeutically effective amount of ascorbic acid or a derivative thereof, and b) a prophylactically and/or therapeutically effective amount of a substance, such as PKF118-130, NCB-0846, PRI-724, siRNA484, siRNA1202, siRNA1387, a compound C-1, and a compound C-2, affecting the formation of a TCF/β-catenin complex.