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![PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE](/abs-image/US/2015/10/01/US20150274707A1/abs.jpg.150x150.jpg)
1.发明申请PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE 审中-公开制备N- [5-（3,5-二氟苯基）-1H-吲哚-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢 - 吡喃-2-基） 4-YLAMINO） - 苯甲酰胺公开(公告)号：US20150274707A1
公开(公告)日：2015-10-01
申请号：US14716986
申请日：2015-05-20
IPC分类号： C07D405/14
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
摘要翻译： 本发明涉及一种制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2 - （四氢 - 吡喃-4-基氨基） - 苯甲酰胺。 这种化合物的新型固体形式，其在治疗由失调的蛋白激酶活性引起的疾病中的用途以及含有它们的药物组合物也是本发明的目的。
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![Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof](/abs-image/US/2016/07/05/US09382235B2/abs.jpg.150x150.jpg)
2.发明授权Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof 有权N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢 - 吡喃-2-基） 吡啶-4-基氨基） - 苯甲酰胺及其使用方法公开(公告)号：US09382235B2
公开(公告)日：2016-07-05
申请号：US14716986
申请日：2015-05-20
IPC分类号： C07D405/12 , A61K31/496 , C07D405/14
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H -indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
摘要翻译： 本发明涉及制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2 - （四氢 - 吡喃-4-基氨基） - 苯甲酰胺。 这种化合物的新型固体形式，其在治疗由失调的蛋白激酶活性引起的疾病中的用途以及含有它们的药物组合物也是本发明的目的。
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![Process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide](/abs-image/US/2015/07/21/US09085565B2/abs.jpg.150x150.jpg)
3.发明授权Process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide 有权制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢 - 吡喃-2-基） 吡啶-4-基氨基） - 苯甲酰胺公开(公告)号：US09085565B2
公开(公告)日：2015-07-21
申请号：US14528475
申请日：2014-10-30
IPC分类号： C07D405/12 , A61K31/496 , C07D405/14
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
摘要翻译： 本发明涉及制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2 - （四氢 - 吡喃-4-基氨基） - 苯甲酰胺。 这种化合物的新型固体形式，其在治疗由失调的蛋白激酶活性引起的疾病中的用途以及含有它们的药物组合物也是本发明的目的。
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![Treatment of diseases through administration of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide](/abs-image/US/2017/05/16/US09649306B2/abs.jpg.150x150.jpg)
公开(公告)号：US09649306B2
公开(公告)日：2017-05-16
申请号：US15172478
申请日：2016-06-03
IPC分类号： C07D405/12 , A61K31/496 , C07D405/14
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
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![PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE](/abs-image/US/2016/09/29/US20160279125A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160279125A1
公开(公告)日：2016-09-29
申请号：US15172478
申请日：2016-06-03
IPC分类号： A61K31/496
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention.
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