公开(公告)号：US20190300599A1

公开(公告)日：2019-10-03

申请号：US16348058

申请日：2017-11-07

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol KIM ,  Jae Young SEONG ,  Jong Ik HWANG ,  Eun Bee CHO ,  Junho CHUNG ,  Junyeong JIN ,  Tae Young YUNE ,  Jee Youn LEE

IPC: C07K16/18 ,  G01N33/563

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.

公开(公告)号：US20220372122A1

公开(公告)日：2022-11-24

申请号：US17723149

申请日：2022-04-18

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol KIM ,  Jae Young SEONG ,  Jong Ik HWANG ,  Eun Bee CHO ,  Junho CHUNG ,  Junyeong JIN ,  Tae Young YUNE ,  Jee Youn LEE

IPC: C07K16/18 ,  G01N33/563 ,  C07K7/00

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.