公开(公告)号：US11332521B2

公开(公告)日：2022-05-17

申请号：US16348058

申请日：2017-11-07

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol Kim ,  Jae Young Seong ,  Jong Ik Hwang ,  Eun Bee Cho ,  Junho Chung ,  Junyeong Jin ,  Tae Young Yune ,  Jee Youn Lee

IPC: C07K16/18 ,  C07K7/00 ,  A61K39/00 ,  G01N33/563

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.

公开(公告)号：US12202889B2

公开(公告)日：2025-01-21

申请号：US17723149

申请日：2022-04-18

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol Kim ,  Jae Young Seong ,  Jong Ik Hwang ,  Eun Bee Cho ,  Junho Chung ,  Junyeong Jin ,  Tae Young Yune ,  Jee Youn Lee

IPC: C07K16/18 ,  A61K39/00 ,  C07K7/00 ,  G01N33/563

Abstract: The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.