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    CD44 SPLICE VARIANTS IN NEURODEGENERATIVE DISEASES
    1.
    发明申请
    CD44 SPLICE VARIANTS IN NEURODEGENERATIVE DISEASES 有权
    CD44 SPLICE变量在神经损伤性疾病中的应用

    公开(公告)号：US20150266940A1

    公开(公告)日：2015-09-24

    申请号：US14671281

    申请日：2015-03-27

    申请人： NEURIM PHARAMCEUTICALS (1991) LTD.

    发明人： Elhanan Pinner ,  Moshe Laudon ,  Nava Zisapel

    IPC分类号： C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/70585 ,  C07K16/2884 ,  C07K2317/76 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6896 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835

    摘要： There is provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression of ribonucleic acid (RNA) encoded by a nucleic acid, wherein the nucleic acid is selected from a group that includes a contiguous nucleotide sequence being at least 90% homologous to at least 20 nucleotides of: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, or any combination thereof. There is further provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression and/or activity of a polypeptide, wherein the sequence of the polypeptide is selected from a group that includes a contiguous amino acid sequence being at least 90% homologous to at least 10 amino acid of: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or any combination thereof.

    摘要翻译： 提供了治疗或预防神经变性疾病的方法，其包括给予包含能够调节由核酸编码的核糖核酸（RNA）表达的试剂的组合物，其中所述核酸选自包括 与SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：7或其任何组合的至少20个核苷酸至少90％同源的连续核苷酸序列。 还提供了治疗或预防神经变性疾病的方法，其包括施用包含能够调节多肽的表达和/或活性的试剂的组合物，其中所述多肽的序列选自包括 连续氨基酸序列与SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8或其任何组合的至少10个氨基酸至少90％同源。