公开(公告)号：US20220259304A1

公开(公告)日：2022-08-18

申请号：US17565994

申请日：2021-12-30

申请人： NEW YORK UNIVERSITY ,  argenx IIP BV

发明人： Steven J. BURDEN ,  Shohei KOIDE ,  Akiko KOIDE ,  Nadia LELOUP ,  Julien OURY ,  Karen SILENCE ,  Roeland VANHAUWAERT ,  Christophe BLANCHETOT

IPC分类号： C07K16/28 ,  A61P21/04

摘要： The present invention relates to antibody-based molecules, including full-length antibodies, antigen-binding domains thereof, and antibody derivatives that are capable of binding to and activating human muscle-specific tyrosine protein kinase (MuSK). The present invention further discloses methods of treating neuromuscular conditions using the aforementioned MuSK antibodies.

公开(公告)号：US20230151091A1

公开(公告)日：2023-05-18

申请号：US17937630

申请日：2022-10-03

申请人： argenx IIP BV ,  New York University

发明人： Steven J. BURDEN ,  Shohei KOIDE ,  Akiko KOIDE ,  Nadia LELOUP ,  Julien OURY ,  Karen SILENCE ,  Roeland VANHAUWAERT ,  Christophe BLANCHETOT

IPC分类号： C07K16/28 ,  A61P21/04

CPC分类号： C07K16/28 ,  A61P21/04 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/622

摘要： The present invention relates to antibody-based molecules, including full-length antibodies, antigen-binding domains thereof, and antibody derivatives that are capable of binding to and activating human muscle-specific tyrosine protein kinase (MuSK). The present invention further discloses methods of treating neuromuscular conditions using the aforementioned MuSK antibodies.