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公开(公告)号：US11802155B2
公开(公告)日：2023-10-31
申请号：US17244169
申请日：2021-04-29
发明人： Dana Yen Mei Duey , Allen James Ebens, Jr. , Daniel David Kaplan , Chia-Ying Kao Lam , Kalyani Mondal , Geoffrey William Stone , Yan Wang
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
CPC分类号： C07K16/2803 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides binding agents, such as antibodies, that specifically bind ILT2, ILT4, or both ILT2 and ILT4, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.
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公开(公告)号：US20240025997A1
公开(公告)日：2024-01-25
申请号：US18466722
申请日：2023-09-13
发明人： Dana Yen Mei Duey , Allen James Ebens, Jr. , Daniel David Kaplan , Chia-Ying Kao Lam , Kalyani Mondal , Geoffrey William Stone , Yan Wang
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
CPC分类号： C07K16/2803 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides binding agents, such as antibodies, that specifically bind ILT2, ILT4, or both ILT2 and ILT4, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.
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公开(公告)号：US20230256070A1
公开(公告)日：2023-08-17
申请号：US18153643
申请日：2023-01-12
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
CPC分类号： A61K39/001154 , C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/75 , G01N33/66
摘要： The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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公开(公告)号：US11596676B2
公开(公告)日：2023-03-07
申请号：US16928862
申请日：2020-07-14
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
IPC分类号： A61K39/395 , A61K39/00 , C07K16/28 , G01N33/66
摘要： The present disclosure provides binding proteins, such as antibodies and binding fragments thereof, that bind beta klotho, including human beta klotho, and methods of their use, including in the treatment of nonalcoholic steatohepatitis. The present disclosure also provides exemplary specific sequences of complementarity determining regions, variable regions, heavy chains, and light chains of the antibodies and/or binding fragments thereof.
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公开(公告)号：US10744191B2
公开(公告)日：2020-08-18
申请号：US16103613
申请日：2018-08-14
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
IPC分类号： A61K39/395 , A61K39/00 , C07K16/28 , G01N33/66
摘要： The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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公开(公告)号：US20190106490A1
公开(公告)日：2019-04-11
申请号：US16103613
申请日：2018-08-14
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
摘要： The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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公开(公告)号：US20210115133A1
公开(公告)日：2021-04-22
申请号：US17005675
申请日：2020-08-28
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
摘要： The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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公开(公告)号：US20210030857A1
公开(公告)日：2021-02-04
申请号：US16928862
申请日：2020-07-14
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
摘要： The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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公开(公告)号：US10800843B2
公开(公告)日：2020-10-13
申请号：US15748111
申请日：2016-07-29
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
IPC分类号： C07K16/18 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
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公开(公告)号：US11667708B2
公开(公告)日：2023-06-06
申请号：US17005675
申请日：2020-08-28
发明人： Kalyani Mondal , Betty Chan Li , Yu Chen , Taruna Arora , Hugo Matern , Wenyan Shen
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/28 , A61K39/001132 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides binding proteins, such as antibodies, and binding fragments thereof, that bind beta klotho, including human beta klotho, and exemplary specific sequences of their complementarity determining regions, variable regions, heavy chains, and light chains. The present disclosure also provides method of making the antibody or fragment thereof and methods of their use, including, in activating beta-klotho/FGF receptor complex, inducing FGF19-like and/or FGF21-like signaling, improving glucose and lipid metabolism, and treatment of nonalcoholic steatohepatitis.
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