公开(公告)号：US20140080997A1

公开(公告)日：2014-03-20

申请号：US14052879

申请日：2013-10-14

申请人： NIPPON ZENYAKU KOGYO CO., LTD.

发明人： Toshihiro TSUKUI ,  Hajime TSUJIMOTO ,  Shigehiro IWABUCHI

IPC分类号： C07K14/435

CPC分类号： C07K14/43531 ,  A61K39/00 ,  A61K39/35 ,  G01N33/56905 ,  G01N33/6854

摘要： A safe and efficient recombinant mite allergen is provided as a therapeutic agent or a diagnostic agent for mite allergic diseases, which contains no anaphylaxis-inducing impurities. The following recombinant protein (a) or (b) is provided:(a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2 or 35; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 or 35 by deletion, substitution, or addition of one or several amino acids and having mite allergen activity.

摘要翻译： 提供安全有效的重组螨变应原作为不含过敏反应性杂质的螨过敏性疾病的治疗剂或诊断剂。 提供以下重组蛋白（a）或（b）：（a）包含SEQ ID NO：2或35所示的氨基酸序列的蛋白质; 或（b）通过缺失，取代或添加一个或几个氨基酸并具有螨变应原活性的蛋白质，其包含由SEQ ID NO：2或35所示的氨基酸序列衍生的氨基酸序列。