公开(公告)号：US20190029969A1

公开(公告)日：2019-01-31

申请号：US15757757

申请日：2016-09-06

Applicant: NIPRO CORPORATION

Inventor： Naoya KOSAKA ,  Naoyuki MIYANAGA ,  Minoru HATSUSHIKA

IPC: A61K9/50 ,  A61K31/519

Abstract: A microcapsule contains a biodegradable polymer and risperidone and has a sustained release property. The biodegradable polymer contained in the microcapsule has a molecular weight corresponding to 85% or more of an initial molecular weight (Mw) of the biodegradable polymer. A method of producing the microcapsule is also disclosed. The method of producing a microcapsule has (A) a step of preparing a first phase by mixing a solution of a biodegradable polymer and a solution of risperidone which are prepared separately, (B) a step of, immediately after the preparation of the first phase, mixing the first phase with a second phase being an aqueous phase to prepare an emulsion, and (C) a step of subjecting the resulting emulsion to in-water drying.

公开(公告)号：US20200281863A1

公开(公告)日：2020-09-10

申请号：US16881277

申请日：2020-05-22

Applicant: NIPRO CORPORATION

Inventor： Naoya KOSAKA ,  Naoyuki MIYANAGA ,  Minoru HATSUSHIKA

IPC: A61K9/50 ,  A61K31/519

Abstract: A microcapsule contains a biodegradable polymer and risperidone and has a sustained release property. The biodegradable polymer contained in the microcapsule has a molecular weight corresponding to 85% or more of an initial molecular weight (Mw) of the biodegradable polymer. A method of producing the microcapsule is also disclosed. The method of producing a microcapsule has (A) a step of preparing a first phase by mixing a solution of a biodegradable polymer and a solution of risperidone which are prepared separately, (B) a step of, immediately after the preparation of the first phase, mixing the first phase with a second phase being an aqueous phase to prepare an emulsion, and (C) a step of subjecting the resulting emulsion to in-water drying.