公开(公告)号：US20190144780A1

公开(公告)日：2019-05-16

申请号：US16098339

申请日：2017-05-01

申请人： NISSHIN PHARMA INC.

发明人： Masataka HARATA ,  Shingo NONAKA ,  Hideki KANAI ,  Hiroyuki IKEMOTO ,  Kenji TAKEMOTO

IPC分类号： C11C1/08

CPC分类号： C11C1/08 ,  C07C67/48 ,  C11B7/00 ,  C12M1/00

摘要： Provided is a method for producing a polyunsaturated fatty acid while preventing deterioration of a silver salt solution. A method for producing a composition comprising a polyunsaturated fatty acid, comprising: supplying an aqueous solution comprising a silver salt into a reaction vessel to contact the aqueous solution with a raw material solution comprising an alkyl ester of the polyunsaturated fatty acid; and collecting the aqueous solution comprising the silver salt which has been contacted with the raw material solution from the reaction vessel, wherein the supply of the aqueous solution comprising the silver salt into the reaction vessel and the collection of the aqueous solution comprising the silver salt from the reaction vessel are carried out concurrently with each other.

公开(公告)号：US20210395183A1

公开(公告)日：2021-12-23

申请号：US17418439

申请日：2019-12-26

申请人： NISSHIN PHARMA INC.

发明人： Ichiro GOTO ,  Masataka HARATA ,  Shingo NONAKA

IPC分类号： C07C69/587 ,  C07C67/54

摘要： Provided is a high-concentration and high-purity eicosapentaenoic acid-containing composition. A method for producing an eicosapentaenoic acid alkyl ester-containing composition, the method includes: (1) bringing a raw oil that contains an eicosapentaenoic acid alkyl ester into contact with an aqueous solution that contains a silver salt, and then collecting an aqueous layer; (2) adding an organic solvent to the aqueous layer, and then collecting an organic solvent layer; and (3) subjecting the organic solvent layer to vacuum distillation at a temperature of 180 to 188° C. and a tower top vacuum degree of 0.7 Pa or below, to recover the eicosapentaenoic acid alkyl ester from the organic solvent layer.

公开(公告)号：US20200172829A1

公开(公告)日：2020-06-04

申请号：US16621464

申请日：2018-06-14

申请人： NISSHIN PHARMA INC.

发明人： Hiroyuki IKEMOTO ,  Kenji TAKEMOTO ,  Masataka HARATA ,  Shingo NONAKA ,  Hideki KANAI

IPC分类号： C11B7/00

摘要： Provided is a method for producing a polyunsaturated fatty acid while suppressing deterioration of a silver salt solution. A method for producing a polyunsaturated fatty acid-containing composition, the method comprising: supplying a raw material solution comprising an alkyl ester of polyunsaturated fatty acid and an aqueous solution comprising a silver salt to a flow channel mixer to contact the raw material solution with the aqueous solution; and collecting the aqueous solution comprising the silver salt which has been contacted with the raw material solution, in which the supplying the aqueous solution comprising the silver salt to the flow channel mixer and the collecting the same are performed concurrently.