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公开(公告)号：US20200381080A1
公开(公告)日：2020-12-03
申请号：US16887850
申请日：2020-05-29
Applicant: NOBLIS, INC.
Inventor： Sterling THOMAS
Abstract: Techniques for determining whether a nucleic acid sequence is genetically engineered are provided. In some embodiments, a ratio is calculated based on a number of input reads that align with reference data, and the ratio is inputted into a classifier to determine whether the input reads represent an engineered sequence. In some embodiments, first output data is generated based on unassembled read-based comparison of nucleic acid data, while second output data is generated based on assembly-based comparison of the nucleic acid data; the first and second output data are inputted into a classifier to determine whether the input data represents an engineered sequence. In some embodiments, nucleic acid data is compared to three reference datasets representing (i) engineered sequences, (ii) evolutionary variations of an organism, and (iii) evolutionary variations of other organisms; a determination as to whether the input data represents an engineered sequence is based on the three comparisons.
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Patent Agency Ranking
公开(公告)号：US20190146962A1
公开(公告)日：2019-05-16
申请号：US16257552
申请日：2019-01-25
Applicant: NOBLIS, INC.
Inventor： Sterling THOMAS , Nathan DELLINGER
Abstract: In some embodiments, techniques for identifying one or more species in an undifferentiated environmental sample comprising a plurality of nucleic acid sequences are provided. One or more indices that represent a plurality of reference nucleic acid sequences may be provided, and data may be received comprising digital representations of respective nucleic acid sequences. The respective nucleic acid sequences may be aligned, if possible, using the indices. A respective alignment ration may be calculated for each one of the reference nucleic acid sequences, based on the number of nucleic acid sequences aligned to the respective reference nucleic acid sequence and the total number of nucleic acid sequences in the received data.
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公开(公告)号：US20220253420A1
公开(公告)日：2022-08-11
申请号：US17723053
申请日：2022-04-18
Applicant: NOBLIS, INC.
Inventor： Sterling THOMAS , Nathan DELLINGER
Abstract: In some embodiments, techniques for identifying one or more species in an undifferentiated environmental sample comprising a plurality of nucleic acid sequences are provided. One or more indices that represent a plurality of reference nucleic acid sequences may be provided, and data may be received comprising digital representations of respective nucleic acid sequences. The respective nucleic acid sequences may be aligned, if possible, using the indices. A respective alignment ration may be calculated for each one of the reference nucleic acid sequences, based on the number of nucleic acid sequences aligned to the respective reference nucleic acid sequence and the total number of nucleic acid sequences in the received data.
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公开(公告)号：US20210324371A1
公开(公告)日：2021-10-21
申请号：US17231280
申请日：2021-04-15
Applicant: NOBLIS, INC.
Inventor： Shane MITCHELL , Masooda OMARI , Sterling THOMAS , Leo THOMPSON
IPC: C12N15/10 , C12Q1/6869 , C12Q1/6806 , B01L7/00
Abstract: A portable kit for nucleic acid sequencing is disclosed, the kit including a DNA extraction system configured to perform a DNA extraction protocol, a DNA sequencing preparation system configured to perform a DNA sequencing preparation protocol, a sequencer system, and a portable enclosure configured to house the DNA extraction system, the sequencer preparation system, and the sequencer system.
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公开(公告)号：US20170124253A1
公开(公告)日：2017-05-04
申请号：US15337754
申请日：2016-10-28
Applicant: NOBLIS, INC.
Inventor： Sterling THOMAS , Karen TAYLOR
Abstract: Systems and methods for identifying pathogens in food using whole genome sequencing are provided. In some embodiments, gene sequence data derived from food pathogen samples are subject to bioinformatics processing in order to align the sequences and detect single-nucleotide polymorphisms (SNP's). In some embodiments, a SNP matrix is generated and a phylogenic tree is created, and it is determined whether the strain of pathogens detected in one food pathogen sample is the same strain of pathogen present in other previously-encountered food pathogen samples. If a match between samples is determined, then metadata associated with the matching samples is leveraged to trace the spread of the strain through a supply chain in space and time, and parties associated with the matching samples may be notified.
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公开(公告)号：US20160344849A1
公开(公告)日：2016-11-24
申请号：US14718950
申请日：2015-05-21
Applicant: NOBLIS, INC.
Inventor： Sterling THOMAS , Nate DELLINGER , Mychal IVANCICH
Abstract: Systems and methods for performing genomic information compression, transmission, and decompression are provided. A system for compression, transmission, and decompression of genomic information includes a first computer associated with a first index and a second computer associated with a second index, each index containing reference permutations of nucleic acid sequence portions, each permutation associated with a reference number. The first computer uses input genomic information and the first index to produce a compressed representation of the genomic information, and transmits the compressed representation to the second computer. The second computer uses the compressed representation and the second index to assemble a data representation of the genomic information. The compressed representation comprises references to permutations, indications of locations of each permutation in the input information, indications of variations to permutations, and/or indications of sequence length.
Abstract translation: 提供了用于执行基因组信息压缩，传输和解压缩的系统和方法。 用于基因组信息的压缩，传输和解压缩的系统包括与第一索引相关联的第一计算机和与第二索引相关联的第二计算机，每个索引包含核酸序列部分的参考排列，每个置换与参考号相关联。 第一计算机使用输入基因组信息和第一索引来产生基因组信息的压缩表示，并将压缩表示传送到第二计算机。 第二台计算机使用压缩表示和第二个索引来组合基因组信息的数据表示。 压缩表示包括对置换的引用，输入信息中每个排列的位置的指示，排列变化的指示和/或序列长度的指示。
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