公开(公告)号：US20200222325A1

公开(公告)日：2020-07-16

申请号：US16640756

申请日：2018-08-30

Applicant: NOVARTIS AG

Inventor： Markus KRUMME ,  Hans DE WAARD ,  Klaus-Peter MOLL ,  Adrian SCHMIDT ,  Frantz ELBAZ ,  Peter KLEINEBUDDE

IPC: A61K9/16 ,  A61K45/06 ,  A61K9/20 ,  A61K9/48

Abstract: In a method for preparing at least partially dried granules, an API, a base powder, and a granulation liquid are fed to a granulator. The API, the base powder and the granulation liquid are mixed within the granulator to produce an API/base powder/granulation liquid mixture. This liquid mixture within the granulator is heated to a heating temperature (TH) that exceeds an evaporation temperature (TE) of the granulation liquid contained in an API/base powder/granulation liquid mixture to allow at least a part of the granulation liquid contained in the API/base powder/granulation liquid mixture to evaporate in order to obtain at least partially dried granules containing at least the API and the base powder. The at least partially dried granules are discharged from the granulator.